Company to Advance its Lead Drug Candidate, TNT009, into
The Series A financing will provide True North with funding to complete Phase 1a and Phase 1b studies with TNT009, including evaluation of patients in a variety of autoantibody-driven rare diseases mediated by the Complement system. The company has completed preclinical studies showing ex vivo efficacy of TNT009, a first-in-class monoclonal antibody that selectively inhibits a target of the Classical Complement pathway.
“True North is on the cutting-edge in the field of therapeutics to target the Complement system,” said
With TNT009, True North is focused on Complement-mediated rare diseases in the hematologic, renal and neurological therapeutic areas. TNT009 inhibits C1s, a member of the Complement family of plasma proteins, which, upon activation, triggers a powerful enzymatic cascade that destroys and removes pathogens from the circulation. Aberrant activation of the Complement system has been described in numerous autoimmune settings in which antibodies that attack self, known as autoantibodies, play a role in disease pathogenesis.
“This financing provides us with a strong financial foundation and firmly validates our investors’ enthusiasm for the promise of TNT009 and the value of implementing a robust clinical program for multiple rare diseases,” said
TNT009 is a first-in-class molecule developed to selectively inhibit C1s, a serine protease specific to the Classical Complement pathway of the immune system. TNT009 selectively inhibits the Classical Complement pathway, thereby preventing downstream disease processes involving phagocytosis, inflammation, and cell lysis. With a unique mechanism of action and high target specificity, TNT009 selectively inhibits disease processes in the Classical Complement pathway cascade while maintaining the important immune surveillance provided by the Alternative Complement Pathway and Lectin Complement Pathway.
About True North Therapeutics
True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms in diseases with high unmet need, including rare diseases. The company’s lead monoclonal antibody drug candidate, TNT009, offers a novel approach for treating Complement-mediated diseases by selectively inhibiting a target in the Classical Complement pathway. True North’s drug development programs are focused on Complement-mediated rare diseases in the hematologic, kidney transplant, dermatology and neurological therapeutic areas. True North Therapeutics is located in
True North Therapeutics
Source: True North Therapeutics