News Column

Reports Outline Biomaterials Study Results from Tel-Aviv University

June 17, 2014



By a News Reporter-Staff News Editor at Journal of Technology -- Investigators publish new report on Biomaterials. According to news reporting originating in Tel Aviv, Israel, by VerticalNews journalists, research stated, "Lacerations and traumatic wounds are considered to be among the most prevalent scenarios encountered in hospitals and emergency rooms. Reattachment of the lacerated soft tissue edges is traditionally performed using sutures."

The news reporters obtained a quote from the research from Tel-Aviv University, "Use of tissue adhesives, i.e. substances that have the ability to firmly attach lacerated tissues back together, has raised interest as an alternative, due to several advantages. Novel tissue adhesives based on the natural polymers gelatin and alginate, and cross-linked by carbodiimide (EDC), were recently developed by our research group. In the current research, two types of hemostatic agents, tranexamic acid and kaolin, were loaded into our gelatin-alginate bioadhesive, in order to improve the adhesion abilities in the hemorrhagic environment of the wound. Their effects on the ex vivo adherence properties, physical properties, and biocompatibility were investigated. Incorporation of kaolin significantly improved the ex vivo bonding strength of the gelatin-alginate-EDC bioadhesives through a combination of three physical mechanisms and decreased the swelling ratio without affecting weight loss. In contradiction, incorporation of tranexamic acid into the bioadhesive formulation resulted in a lower ex vivo bonding strength and a higher swelling ratio and weight loss, probably due to reduced efficiency of the cross-linking reaction between the molecules of the natural polymers and the cross-linking agent EDC. The hemostatic agent-loaded bioadhesives showed good biocompatibility when tested in vitro on fibroblast cells."

According to the news reporters, the research concluded: "This research clearly shows that the incorporation of kaolin in our gelatin-alginate tissue adhesives may be a very promising novel approach for improving the bonding strength and physical properties of the tissue adhesives for use in hemorrhagic environments."

For more information on this research see: Effect of hemostatic agents on properties of gelatin-alginate soft tissue adhesives. Journal of Biomaterials Science Polymer Edition, 2014;25(6):555-73.

Our news correspondents report that additional information may be obtained by contacting O. Pinkas, a Faculty of Engineering, Dept. of Biomedical Engineering , Tel-Aviv University , Tel-Aviv 69978 , Israel.

Keywords for this news article include: Asia, Israel, Tel Aviv, Biomaterials.

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Source: Journal of Technology