News Column

New Hydroxides Findings from University Putra Malaysia Described

June 20, 2014

By a News Reporter-Staff News Editor at Science Letter -- New research on Hydroxides is the subject of a report. According to news reporting originating from Selangor, Malaysia, by NewsRx correspondents, research stated, "Layered hydroxide nanoparticles are generally biocompatible, and less toxic than most inorganic nanoparticles, making them an acceptable alternative drug delivery system. Due to growing concern over animal welfare and the expense of in vivo experiments both the public and the government are interested to find alternatives to animal testing."

Our news editors obtained a quote from the research from University Putra Malaysia, "The toxicity potential of zinc aluminum layered hydroxide (ZAL) nanocomposite containing anti-Parkinsonian agent may be determined using a PC 12 cell model. ZAL nanocomposite demonstrated a decreased cytotoxic effect when compared to levodopa on PC12 cells with more than 80% cell viability at 100 g/mL compared to less than 20% cell viability in a direct levodopa exposure. Neither levodopa-loaded nanocomposite nor the un-intercalated nanocomposite disturbed the cytoskeletal structure of the neurogenic cells at their IC50 concentration."

According to the news editors, the research concluded: "Levodopa metabolite (HVA) released from the nanocomposite demonstrated the slow sustained and controlled release character of layered hydroxide nanoparticles unlike the burst uptake and release system shown with pure levodopa treatment."

For more information on this research see: Toxicity and metabolism of layered double hydroxide intercalated with levodopa in a Parkinson's disease model. International Journal of Molecular Sciences, 2014;15(4):5916-27 (see also Hydroxides).

The news editors report that additional information may be obtained by contacting A.U. Kura, Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, Selangor 43400, Malaysia. Additional authors for this research include N.M. Ain, M.Z. Hussein, S. Fakurazi and S.H Hussein-Al-Ali.

Keywords for this news article include: Asia, Anions, Selangor, Malaysia, Alkalies, Hydroxides, Nanoparticle, Nanotechnology, Inorganic Chemicals, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Science Letter

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