Our news editors obtained a quote from the research from ISMN, "Nanogels (NGs) were proved not to be cytotoxic at the cellular level. Indeed, they rapidly bypass the cellular membrane to accumulate in specific cell portions of the cytoplasm, in the perinuclear area. The availability of pendant carboxyl groups on the crosslinked PVP NGs core prompted us to attempt their decoration with a single strand oligonucleotide, which holds a terminal amino group."
According to the news editors, the research concluded: "The recognition ability of the attached single helix of its complementary strand was investigated."
For more information on this research see: Oligonucleotides-Decorated-Poly(N-vinyl pyrrolidone) Nanogels for Gene Delivery.
The news editors report that additional information may be obtained by contacting
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