News Column

Findings on Applied Polymer Science Detailed by Investigators at ISMN

June 17, 2014



By a News Reporter-Staff News Editor at Journal of Technology -- Investigators publish new report on Applied Polymer Science. According to news reporting originating from Palermo, Italy, by VerticalNews correspondents, research stated, "Pulsed electron-beam irradiation of a semi-dilute poly(N-vinyl pyrrolidone) (PVP) aqueous solution in the presence of acrylic acid has led to a carboxyl functionalized nanogel system. Nanoparticles hydrodynamic size and surface charge density, in water and as a function of pH, were investigated by dynamic light scattering and laser doppler velocimetry, respectively."

Our news editors obtained a quote from the research from ISMN, "Nanogels (NGs) were proved not to be cytotoxic at the cellular level. Indeed, they rapidly bypass the cellular membrane to accumulate in specific cell portions of the cytoplasm, in the perinuclear area. The availability of pendant carboxyl groups on the crosslinked PVP NGs core prompted us to attempt their decoration with a single strand oligonucleotide, which holds a terminal amino group."

According to the news editors, the research concluded: "The recognition ability of the attached single helix of its complementary strand was investigated."

For more information on this research see: Oligonucleotides-Decorated-Poly(N-vinyl pyrrolidone) Nanogels for Gene Delivery. Journal of Applied Polymer Science, 2014;131(2):236-243. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)

The news editors report that additional information may be obtained by contacting C. Dispenza, CNR Ist Studio Mat Nanostrutturati ISMN UOS Paler, I-90146 Palermo, Italy. Additional authors for this research include G. Adamo, M.A. Sabatino, N. Grimaldi, D. Bulone, M.L. Bondi, S. Rigogliuso and G. Ghersi.

Keywords for this news article include: Italy, Europe, Palermo, Applied Polymer Science

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Source: Journal of Technology