By a News Reporter-Staff News Editor at Science Letter -- Current study results on Molecular Recognition have been published. According to news reporting from Tianjin, People's Republic of China, by NewsRx journalists, research stated, "A facile and highly efficient new approach (namely RAFT coupling chemistry) to obtain well-defined hydrophilic molecularly imprinted polymer (MIP) microspheres with excellent specific recognition ability toward small organic analytes in the real, undiluted biological samples is described. It involves the first synthesis of 'living' MIP microspheres with surface-bound vinyl and dithioester groups via RAFT precipitation polymerization (RAFTPP) and their subsequent grafting of hydrophilic polymer brushes by the simple coupling reaction of hydrophilic macro-RAFT agents (i.e., hydrophilic polymers with a dithioester end group) with vinyl groups on the 'living' MIP particles in the presence of a free radical initiator."
The news correspondents obtained a quote from the research from Nankai University, "The successful grafting of hydrophilic polymer brushes onto the obtained MIP particles was confirmed by SEM, FT-IR, static contact angle and water dispersion studies, elemental analyses, and template binding experiments. Well-defined MIP particles with densely grafted hydrophilic polymer brushes (similar to 1.8 chains/nm(2)) of desired chemical structures and molecular weights were readily obtained, which showed significantly improved surface hydrophilicity and could thus function properly in real biological media. The origin of the high grafting densities of the polymer brushes was clarified and the general applicability of the strategy was demonstrated."
According to the news reporters, the research concluded: "In particular, the well-defined characteristics of the resulting hydrophilic MIP particles allowed the first systematic study on the effects of various structural parameters of the grafted hydrophilic polymer brushes on their water-compatibility, which is of great importance for rationally designing more advanced real biological sample-compatible MIPs."
For more information on this research see: Well-Defined Hydrophilic Molecularly Imprinted Polymer Microspheres for Efficient Molecular Recognition in Real Biological Samples by Facile RAFT Coupling Chemistry. Biomacromolecules, 2014;15(5):1663-1675. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
Our news journalists report that additional information may be obtained by contacting M. Zhao, Nankai Univ, Coll Chem, Tianjin 300071, People's Republic of China. Additional authors for this research include X.J. Chen, H.T. Zhang, H.S. Yan and H.Q. Zhang (see also Molecular Recognition).
Keywords for this news article include: Asia, Tianjin, Chemicals, Chemistry, Nanotechnology, Emerging Technologies, Molecular Recognition, People's Republic of China
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