News Column

University of Central Florida Describes Findings in Peripheral Nerves

June 17, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Peripheral Nervous System. According to news reporting out of Orlando, Florida, by NewsRx editors, research stated, "One of the most important developmental modifications of the nervous system is Schwann cell myelination of axons. Schwann cells ensheath axons to create myelin segments to provide protection to the axon as well as increase the conduction of action potentials."

Our news journalists obtained a quote from the research from the University of Central Florida, "In vitro neuronal systems provide a unique modality to study a variety of factors influencing myelination as well as diseases associated with myelin sheath degradation. This work details the development of a patterned in vitro myelinating dorsal root ganglion culture. This defined system utilized a serum-free medium in combination with a patterned substrate, utilizing the cytophobic and cytophilic molecules (poly)ethylene glycol (PEG) and N-1[3 (trimethoxysilyl) propyl] diethylenetriamine (DETA), respectively. Directional outgrowth of the neurites and subsequent myelination was controlled by surface modifications, and conformity to the pattern was measured over the duration of the experiments. The myelinated segments and nodal proteins were visualized and quantified using confocal microscopy. This tissue-engineered system provides a highly controlled, reproducible model for studying Schwann cell interactions with sensory neurons, as well as the myelination process, and its effect on neuronal plasticity and peripheral nerve regeneration. It is also compatible for use in bio-hybrid constructs to reproduce the stretch reflex arc on a chip because the media combination used is the same that we have used previously for motoneurons, muscle, and for neuromuscular junction (NMJ) formation."

According to the news editors, the research concluded: "This work could have application for the study of demyelinating diseases such as diabetes induced peripheral neuropathy and could rapidly translate to a role in the discovery of drugs promoting enhanced peripheral nervous system (PNS) remyelination."

For more information on this research see: Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system. In Vitro Cellular & Developmental Biology Animal, 2013;49(8):608-18 (see also Peripheral Nervous System).

Our news journalists report that additional information may be obtained by contacting J.W. Rumsey, NanoScience Technology Center, University Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL, 32826, United States. Additional authors for this research include C. McAleer, M. Das, A. Bhalkikar, K. Wilson, M. Stancescu, S. Lambert and J.J Hickman.

Keywords for this news article include: Orlando, Florida, Neurons, Neuroglia, United States, Schwann Cells, Peripheral Nerves, North and Central America, Peripheral Nervous System.

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Source: Life Science Weekly