By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Cytoplasmic Structures. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Weibel-Palade bodies (WPBs), endothelial-specific secretory granules that are central to primary hemostasis and inflammation, occur in dimensions ranging between 0.5 and 5 mm. How their size is determined and whether it has a functional relevance are at present unknown."
Our news editors obtained a quote from the research from University College London, "Here, we provide evidence for a dual role of the Golgi apparatus in controlling the size of these secretory carriers. At the ministack level, cisternae constrain the size of nanostructures ('quanta') of von Willebrand factor (vWF), the main WPB cargo. The ribbon architecture of the Golgi then allows copackaging of a variable number of vWF quanta within the continuous lumen of the trans-Golgi network, thereby generating organelles of different sizes. Reducing the WPB size abates endothelial cell hemostatic function by drastically diminishing platelet recruitment, but, strikingly, the inflammatory response (the endothelial capacity to engage leukocytes) is unaltered."
According to the news editors, the research concluded: "Size can thus confer functional plasticity to an organelle by differentially affecting its activities."
For more information on this research see: A Two-Tier Golgi-Based Control of Organelle Size Underpins the Functional Plasticity of Endothelial Cells. Developmental Cell, 2014;29(3):292-304. Developmental Cell can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Developmental Cell - www.elsevier.com/wps/product/cws_home/622228)
The news editors report that additional information may be obtained by contacting F. Ferraro, UCL, Electron Microscopy Lab, Lab Mol & Cellular Biol, London WC1E 6BT, United Kingdom. Additional authors for this research include J. Kriston-Vizi, D.J. Metcalf, B. Martin-Martin, J. Freeman, J.J. Burden, D. Westmoreland, C.E. Dyer, A.E. Knight, R. Ketteler and D.F. Cutler (see also Cytoplasmic Structures).
Keywords for this news article include: London, Europe, Organelles, United Kingdom, Endothelial Cells, Cellular Structures, Intracellular Space, Cytoplasmic Structures
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