By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Life Science Research have been presented. According to news reporting originating in Livermore, California, by NewsRx journalists, research stated, "Nanoparticles hold great promise for the delivery of therapeutics, yet limitations remain with regards to the use of these nanosystems for efficient long-lasting targeted delivery of therapeutics, including imparting functionality to the platform, in vivo stability, drug entrapment efficiency and toxicity. To begin to address these limitations, we evaluated the functionality, stability, cytotoxicity, toxicity, immunogenicity and in vivo biodistribution of nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs)."
The news reporters obtained a quote from the research from Lawrence Livermore National Laboratory, "We found that a wide range of molecules could be reliably conjugated to the NLP, including proteins, single-stranded DNA, and small molecules. The NLP was also found to be relatively stable in complex biological fluids and displayed no cytotoxicity in vitro at doses as high as 320 g/ml. In addition, we observed that in vivo administration of the NLP daily for 14 consecutive days did not induce significant weight loss or result in lesions on excised organs. Furthermore, the NLPs did not display overt immunogenicity with respect to antibody generation. Finally, the biodistribution of the NLP in vivo was found to be highly dependent on the route of administration, where intranasal administration resulted in prolonged retention in the lung tissue."
According to the news reporters, the research concluded: "Although only a select number of NLP compositions were evaluated, the findings of this study suggest that the NLP platform holds promise for use as both a targeted and non-targeted in vivo delivery vehicle for a range of therapeutics."
For more information on this research see: Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform. Plos One, 2014;9(3):e93342. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news correspondents report that additional information may be obtained by contacting N.O. Fischer, Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California, United States. Additional authors for this research include D.R. Weilhammer, A. Dunkle, C. Thomas, M. Hwang, M. Corzett, C. Lychak, W. Mayer, S. Urbin, N. Collette, J. Chiun Chang, G.G. Loots, A. Rasley and C.D Blanchette (see also Life Science Research).
Keywords for this news article include: Livermore, California, United States, Life Science Research, North and Central America.
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