News Column

Study Data from University of Leeds Update Knowledge of Tissue Engineering

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Biomedicine and Biomedical Engineering is now available. According to news reporting originating from Leeds, United Kingdom, by NewsRx correspondents, research stated, "The aim of this work is to demonstrate that the structural and fluidic properties of polymer foam tissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is supported by measurements of fluid uptake during insonification and imaging of the scaffold microstructure via X-ray computed tomography, scanning electron microscopy and acoustic microscopy."

Our news editors obtained a quote from the research from the University of Leeds, "The ultrasonic treatment is performed with a frequency of 30 kHz, average intensities up to 80,000 Wm(-2) and exposure times up to 20 h. The treatment is found to increase the mean pore size by over 10%. More striking is the improvement in fluid uptake: for scaffolds with only 40% water uptake via standard immersion techniques, we can routinely achieve full saturation of the scaffold over approximately one hour of exposure. These desirable modifications occur with negligible loss of scaffold integrity and mass, and are optimized when the ultrasound treatment is coupled to a pre-wetting stage with ethanol."

According to the news editors, the research concluded: "Our findings suggest that high power ultrasound is highly targeted towards flow obstructions in the scaffold architecture, thereby providing an efficient means to promote pore interconnectivity and fluid transport in thick foam tissue scaffolds."

For more information on this research see: Post-processing of polymer foam tissue scaffolds with high power ultrasound: a route to increased pore interconnectivity, pore size and fluid transport. Materials Science & Engineering C, Materials for Biological Applications, 2013;33(8):4825-32 (see also Biomedicine and Biomedical Engineering).

The news editors report that additional information may be obtained by contacting N.J. Watson, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK. Additional authors for this research include R.K. Johal, Z. Glover, Y. Reinwald, L.J. White, A.M. Ghaemmaghami, S.P. Morgan, F.R. Rose, M.J. Povey and N.G Parker.

Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Leeds, Europe, United Kingdom, Bioengineering.

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Source: Biotech Week

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