News Column

Studies from University of Michigan Health System Yield New Data on Hypothermia

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Hypothermia are presented in a new report. According to news reporting from Ann Arbor, Michigan, by NewsRx journalists, research stated, "Hypothermia improves clinical outcomes and brain magnetic resonance imaging (MRI) findings in infants with hypoxic-ischemic encephalopathy. We hypothesized that clinical status following hypothermia predicts brain MRI abnormalities, and helps determine which infants need an early MRI evaluation before discharge."

The news correspondents obtained a quote from the research from the University of Michigan Health System, "The objective of this study was to determine whether the clinical evaluation 1 week after completion of 72 h of hypothermia treatment predicts the presence of brain MRI abnormalities related to hypoxia-ischemia. The medical records of 83 consecutively cooled infants who underwent brain MRI were reviewed. Clinical evaluation by day 10 of life consisted of assessment of oral feeding ability, spontaneous activity, need for mechanical ventilation and a history of clinical seizures. Logistic regression analysis was performed using all four covariates, with an abnormal MRI as the primary outcome. Brain MRI with lesions in both the basal nuclei and the cortex was considered to be severely abnormal. MRI was abnormal in 46 (55%) infants. Univariate analysis identified all of the criteria as being significantly associated with an abnormal MRI. On multivariate analysis, only feeding difficulty (p

According to the news reporters, the research concluded: "This simple assessment provides significant prognostic information that can be useful in parental counseling, and may allow selective use of pre-discharge MRI."

For more information on this research see: Does clinical status 1 week after therapeutic hypothermia predict brain MRI abnormalities? Journal of Perinatology, 2013;33(7):538-42. Journal of Perinatology can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. (Nature Publishing Group -; Journal of Perinatology -

Our news journalists report that additional information may be obtained by contacting S. Sarkar, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, CS Mott Children's Hospital, Ann Arbor, MI 48109-5254, United States. Additional authors for this research include I. Bhagat, J.R. Bapuraj, R.E. Dechert and S.M Donn (see also Hypothermia).

Publisher contact information for the Journal of Perinatology is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA.

Keywords for this news article include: Therapy, Michigan, Ann Arbor, Hypothermia, United States, North and Central America.

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Source: Biotech Week

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