News Column

Studies from University of Granada in the Area of Tetracyclines Reported

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Tetracyclines are discussed in a new report. According to news reporting originating in Granada, Spain, by NewsRx journalists, research stated, "A nanocomposite based on chitosan and montmorillonite was developed as carrier to improve oral bioavailability of oxytetracycline. The nanocomposite was prepared by simple solid-liquid interaction and loaded with the drug."

The news reporters obtained a quote from the research from the University of Granada, "The loaded nanocomposite was characterized by X-ray powder diffraction, thermal analysis, FTIR spectroscopy and zeta potential. Caco-2 cell cultures were used to evaluate in vitro cytotoxicity and drug permeation. Confocal laser scanning microscopy was also performed to evaluate the eventual entrapment of drug into the Caco-2 cells."

According to the news reporters, the research concluded: "Results showed that the nanocomposite was internalized into the cells and effectively enhanced drug permeation, being also biocompatible towards Caco-2 cells."

For more information on this research see: Intestinal permeability of oxytetracycline from chitosan-montmorillonite nanocomposites. Colloids and Surfaces B-Biointerfaces, 2014;117():441-448. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Tetracyclines).

Our news correspondents report that additional information may be obtained by contacting I. Salcedo, University of Granada, CSIC, Andalusian Inst Earth Sci, Granada 18100, Spain. Additional authors for this research include G. Sandri, C. La Aguzzi, C. Bonferoni, P. Cerezo, R. Sanchez-Espejo and C. Viseras.

Keywords for this news article include: Spain, Europe, Granada, Nanocomposite, Nanotechnology, Oxytetracycline, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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