News Column

Studies from Sichuan University Reveal New Findings on Medicinal Chemistry

June 20, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Health and Medicine have been published. According to news reporting originating in Chengdu, People's Republic of China, by NewsRx journalists, research stated, "Routine clinical implementation of human gene therapy requires safe and efficient gene delivery methods. Linear biodegradable polyesters with carbon-carbon double bonds are prepared from unsaturated diacids and diols."

The news reporters obtained a quote from the research from Sichuan University, "Subsequent appending of low molecular weight PEI by Michael addition gives target cationic polymers efficiently. Agarose gel retardation and fluorescence quenching assays show that these materials have good DNA binding ability and can completely retard plasmid DNA at weight ratio of 0.8. The formed polyplexes have appropriate sizes around 275 nm and zeta-potential values about +20 -35 mV. The cytotoxicities of these polymers assayed by MTT are much lower than that of 25 kDa PEI."

According to the news reporters, the research concluded: "In vitro transfection toward 7402, HEK293 and U-2OS cells show that polymer P1 may give dramatically higher transfection efficiency (TE) than 25 kDa PEI, especially in U-2OS cells, suggesting that such polymer might be promising non-viral gene vectors."

For more information on this research see: Low molecular weight PEI-appended polyesters as non-viral gene delivery vectors. European Journal of Medicinal Chemistry, 2014;78():118-125. European Journal of Medicinal Chemistry can be contacted at: Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France. (Elsevier -; European Journal of Medicinal Chemistry -

Our news correspondents report that additional information may be obtained by contacting M.M. Xun, Sichuan University, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, People's Republic of China. Additional authors for this research include Y.H. Liu, Q. Guo, J. Zhang, Q.F. Zhang, W.X. Wu and X.Q. Yu (see also Health and Medicine).

Keywords for this news article include: Asia, Viral, Virus, Chengdu, Health and Medicine, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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