By a News Reporter-Staff News Editor at Biotech Week -- A new study on Oncology is now available. According to news reporting from Kyoto, Japan, by NewsRx journalists, research stated, "Tumor-associated macrophages (TAMs) negatively affect the therapeutic effects of anticancer agents. To examine the role of TAMs in interferon (IFN)-gamma gene therapy, we selected two types of solid tumors, which varied in the number of TAMs, and investigated the effects of IFN-gamma gene transfer on tumor growth."
The news correspondents obtained a quote from the research from Kyoto University, "Many TAMs were detected in the solid tumors of murine adenocarcinoma colon-26 cells, whereas few TAMs were detected in murine melanoma B16-BL6 cells. IFN-gamma gene transfer hardly suppressed the growth of colon-26 tumors, whereas it was effective in suppressing the growth of B16-BL6 tumors. The antiproliferative effects of IFN-gamma on cultured colon-26 cells were similar to those on cultured B16-BL6 cells. To evaluate the role of TAMs, we injected clodronate liposomes (CLs) modified with poly(ethylene glycol) (PEG) to functionally deplete TAMs in tumor-bearing mice. Repeated injections of PEG-CLs significantly retarded the growth of colon-26 tumors and combination with IFN-gamma gene transfer further inhibited the growth. In contrast, PEG-CLs hardly retarded the growth of B16-BL6 tumors."
According to the news reporters, the research concluded: "These results clearly indicate that TAM depletion is effective in enhancing the therapeutic effect of IFN-gamma in TAM-repleted and IFN-gamma-resistant tumors."
For more information on this research see: Enhancement of Anticancer Effect of Interferon-gamma Gene Transfer against Interferon-gamma-Resistant Tumor by Depletion of Tumor-Associated Macrophages. Molecular Pharmaceutics, 2014;11(5):1542-1549. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)
Our news journalists report that additional information may be obtained by contacting T. Kiyota, Kyoto University, Grad Sch Pharmaceut Sci, Dept. of Mol Microbiol, Sakyo Ku, Kyoto 6068501, Japan. Additional authors for this research include Y. Takahashi, K. Watcharanurak, M. Nishikawa, S. Ohara, M. Ando, Y. Watanabe and Y. Takakura (see also Oncology).
Keywords for this news article include: Asia, Kyoto, Japan, Therapy, Oncology, Cytokines, Immunology, Lymphokines, Myeloid Cells, Interferon-gamma, Biological Factors, Connective Tissue Cells, Mononuclear Phagocyte System, Macrophage-Activating Factors, Intercellular Signaling Peptides and Proteins
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