By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Stem Cell Research. According to news reporting from Washington, District of Columbia, by NewsRx journalists, research stated, "The objective of this study was to design a biomimetic and bioactive tissue-engineered bone construct via a cold atmospheric plasma (CAP) treatment for directed osteogenic differentiation of human bone morrow mesenchymal stem cells (MSCs). Porous nanocrystalline hydroxyapatite/chitosan scaffolds were fabricated via a lyophilization procedure."
The news correspondents obtained a quote from the research from George Washington University, "The nanostructured bone scaffolds were then treated with CAP to create a more favorable surface for cell attachment, proliferation, and differentiation. The CAP-modified scaffolds were characterized via scanning electron microscope, Raman spectrometer, contact angle analyzer, and white light interferometer. In addition, optimal CAP treatment conditions were determined. Our in vitro study shows that MSC adhesion and infiltration were significantly enhanced on CAP modified scaffolds. More importantly, it was demonstrated that CAP-modified nanostructured bone constructs can greatly promote total protein, collagen synthesis, and calcium deposition after 3 weeks of culture, thus making them a promising implantable scaffold for bone regeneration. Moreover, the fibronectin and vitronection adsorption experiments by enzyme-linked immunosorbent assay demonstrated that more adhesion-mediated protein adsorption on the CAP-treated scaffolds. Since the initial specific protein absorption on scaffold surfaces can lead to further recruitment as well as activation of favorable cell functions, it is suggested that our enhanced stem cell growth and osteogenic function may be related to more protein adsorption resulting from surface roughness and wettability modification."
According to the news reporters, the research concluded: "The CAP modification method used in this study provides a quick one-step process for cell-favorable tissue-engineered scaffold architecture remodeling and surface property alteration."
For more information on this research see: Design of Biomimetic and Bioactive Cold Plasma-Modified Nanostructured Scaffolds for Enhanced Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells. Tissue Engineering Part A, 2014;20(5-6):1060-1071. Tissue Engineering Part A can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA (see also Stem Cell Research).
Our news journalists report that additional information may be obtained by contacting M.A. Wang, George Washington University, Dept. of Med, Washington, DC 20052, United States. Additional authors for this research include X.Q. Cheng, W. Zhu, B. Holmes, M. Keidar and L.G. Zhang.
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Washington, Biomimetics, Bone Marrow, United States, Bone Research, Immune System, Bioengineering, Bionanotechnology, Bone Regeneration, Nanobiotechnology, Stem Cell Research, District of Columbia, Emerging Technologies, Regeneration Medicine, Mesenchymal Stem Cells
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