News Column

Researchers' Work from McGill University Focuses on Nanofibers

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Nanofibers are discussed in a new report. According to news reporting originating from Montreal, Canada, by NewsRx correspondents, research stated, "Most fatalities from trauma occur due to severe blood loss. There is a need for improved hemostatic biomaterials that can address this problem."

Our news editors obtained a quote from the research from McGill University, "The aim of this study was to determine the in vivo efficacy of nanofibrous microspheres (NFM) loaded with hemostatic peptides, specifically ideal amphipathic peptides (IAP) that have been demonstrated to possess both procoagulant and antifibrinolyic activities. We demonstrate that IAP can be coupled to NFM (IAP-NFM) to form matrices that exhibit substantial hemostatic activity. IAP-NFM matrices were compared to a commercial zeolitic hemostatic biomaterial (QuikClot) and have superior efficacy in reducing bleeding in vivo. In both a murine tail transection and a murine hepatic injury model, bleeding times were significantly reduced (p

According to the news editors, the research concluded: "In summary, NFM was able to maintain the pro-coagulant properties of IAP in our preclinical model, caused no observable tissue damage at the site of application and had better performance than QuikClot controls."

For more information on this research see: Amphiphilic peptide-loaded nanofibrous calcium phosphate microspheres promote hemostasis in vivo. Acta Biomaterialia, 2013;9(11):9194-200. (Elsevier -; Acta Biomaterialia -

The news editors report that additional information may be obtained by contacting J. Wu, Lady Davis Institute for Medical Research, Dept. of Medicine, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Additional authors for this research include C.A. Lemarie, J. Barralet and M.D Blostein (see also Nanofibers).

Keywords for this news article include: Quebec, Canada, Anions, Montreal, Nanofibers, Nanofibrous, Nanotechnology, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds, Emerging Technologies, North and Central America.

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Source: Life Science Weekly

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