News Column

Researchers Submit Patent Application, "Device and Method for Salvaging Myocardium following Heart Attack", for Approval

June 19, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- From Washington, D.C., NewsRx journalists report that a patent application by the inventors NAU, JR., WILLIAM H. (LONGMONT, CO), filed on October 15, 2013, was made available online on June 5, 2014 (see also Covidien Lp).

The patent's assignee is Covidien Lp.

News editors obtained the following quote from the background information supplied by the inventors: "The following relates generally to systems, devices and related methods of treating a heart. More specifically, the present disclosure relates to treating damaged tissue of a heart after a heart attack using heat shock proteins.

"The World Health Organization (WHO) estimates that nearly 15% of worldwide deaths are due to myocardial infarction (heart attacks) resulting from ischemic heart disease and is the leading cause of death in developing countries. Heart attacks occur when blood supply to regions of the heart is interrupted, thereby leading to ischemia and later damage or death of heart muscle tissue (myocardium). In order to improve chances for recovery after a heart attack, it may be beneficial to salvage more of the myocardium to reduce the infarct size after reperfusion."

As a supplement to the background information on this patent application, NewsRx correspondents also obtained the inventors' summary information for this patent application: "The described features generally relate to one or more improved systems, methods, and/or apparatuses for treating the heart, such as treating ischemia in heart tissue after a heart attack. The heart tissue may be treated by providing heat shock proteins (HSPS) in the tissue. The heat shock proteins may provide myocardial protection for the heart tissue. The heat shock proteins may be provided using, for example, an energy-based device that generates heat in the heart tissue, which stimulates automatic generation of the heat shock proteins by the tissue. The energy-based device may include, for example, an ultrasound device. In another example, the heat shock proteins are applied onto a surface of or injected into the heart tissue. The energy-based device may be used to drive the heat shock proteins into the heart tissue. Various systems, devices and methods may be used to treat the heart tissue in relation a heart attack using heat shock proteins.

"An example method may be directed to a method of treating ischemia in heart tissue after a heart attack. The method can include providing a heat treatment device comprising a heating element, positioning the heating element in proximity to the heart tissue, and heating the heart tissue with the heating element to generate release of heat shock proteins in the heart tissue. The heat shock proteins can provide myocardial protection for the heart tissue.

"Heating the heart tissue can include directing ultrasound waves into the heart tissue. The ultrasound waves can have a frequency in the range of about 1 MHz to about 10 MHz. The method can include delivering a drug to the heart tissue, wherein the drug comprises heat shock proteins. The method can include driving the drug into the heart tissue with the ultrasound waves. The method can include injecting the drug into the heat tissue. The drug can comprise an adenovirus vector.

"Another example method may be directed to method of providing myocardial protection in the heart after myocardial infarction. The method can include providing a heart tissue treatment device, positioning the heart tissue treatment device in proximity to the heart, and utilizing the heart tissue treatment device to provide heat shock proteins to tissue of the heart for myocardial protection.

"Positioning the heart tissue treatment device can include positioning a portion of the heart tissue treatment device in contact with an exterior surface of the heart. The method can include heating the tissue using the heart tissue treatment device to generate the heat shock proteins. Positioning the heart tissue treatment device can include inserting a portion of the heart tissue treatment device through a vessel into the heart. The method can include providing a fluid interface between the heart tissue treatment device and the tissue of the heart.

"A further example method may be directed to a method of treating heart tissue damaged during a heart attack. The method can include reperfusing an artery of the heart to create blood flow to the heart tissue, and heating the heart tissue to a temperature of no more than about 7.degree. C. above body temperature to trigger release of heat shock proteins in the heart tissue.

"Heating the heart tissue can include generating heat using one of an ultrasound device, a radio frequency device, a resistive heating member, a microwave device, and a laser heating member. Heating the heart tissue can include heating from outside of the heart. Alternatively, heating the heart tissue can include heating from inside of the heart. The method can include heating the heart tissue to a temperature of about 37.degree. C. to about 44.degree. C. Heating can be provided by a heating element, and a fluid interface can be provided between the heating element and the heart tissue. The method can include providing a heating element carried by a catheter, which is inserted through a vessel to the heart. The catheter can include a reperfusion member operable to provide the reperfusing, and the heating element can be positioned on the catheter at a location distal of the reperfusion member.

"A heart treatment device can include a delivery member, a heating element, and a tissue interface portion. The delivery member can have a distal support portion. The heating element can be carried by the distal support portion and configured to generate heat to increase a temperature in heart tissue. The tissue interface portion can be positioned between the heating element and the heart tissue.

"The heating element can include an ultrasound device. The ultrasound device can generate ultrasound in the range of about 1 MHz to about 10 MHz. The delivery member can include an elongate instrument configured to be inserted through a wall of a patient's chest cavity to access the heart. The heating element can be positioned outside of the heart. The tissue interface can include a fluid-filled balloon. The delivery member can include a catheter that is insertable within the heart. The catheter can comprise a reperfusion member positioned proximal of the heating element. The reperfusion member can comprise at least one of an expandable balloon and a stent. The tissue interface can comprise a vest carried by a patient. The vest can position the heating element along an exterior of the patient at a predetermined location relative to the heart. The heating element can comprise a rectangularly shaped radially outward facing surface.

"The foregoing has outlined rather broadly the features and technical advantages of examples according to the disclosure in order that the detailed description that follows may be better understood. Additional features and advantages will be described hereinafter. The conception and specific examples disclosed may be readily utilized as a basis for modifying or designing other structures for carrying out the same purposes of the present disclosure. Such equivalent constructions do not depart from the spirit and scope of the appended claims. Features which are believed to be characteristic of the concepts disclosed herein, both as to their organization and method of operation, together with associated advantages will be better understood from the following description when considered in connection with the accompanying figures. Each of the figures is provided for the purpose of illustration and description only, and not as a definition of the limits of the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

"A further understanding of the nature and advantages of the embodiments may be realized by reference to the following drawings. In the appended figures, similar components or features may have the same reference label. Further, various components of the same type may be distinguished by following the reference label by a dash and a second label that distinguishes among the similar components. If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.

"FIG. 1 shows schematically a heart treatment device used to treat damaged tissue in a heart.

"FIG. 2 shows an example heart treatment device contacting an outer surface of a heart in accordance with the present disclosure.

"FIG. 3 shows the heart treatment device of FIG. 2 advanced through a chest wall of a patient and into contact with an outer surface of the heart.

"FIG. 4 shows a distal portion of another example heart treatment device in accordance with the present disclosure.

"FIG. 5 shows a distal end portion of another example heart treatment device in accordance with the present disclosure.

"FIG. 6 shows a distal end portion of another example heart treatment device in the form of a catheter in accordance with the present disclosure.

"FIG. 7 shows a distal end portion of another example heart treatment device in the form of a catheter in accordance with the present disclosure.

"FIG. 8 shows the heart treatment of FIG. 7 inserted through a vessel of a heart.

"FIG. 9 shows a distal end portion of another example heart treatment device inserted in a heart vessel in accordance with the present disclosure.

"FIGS. 10A and 10B show a distal end portion of another example heart treatment device in combination with a reperfusion device in accordance with the present disclosure.

"FIG. 11 shows another example heart treatment device for use in treating a heart from outside of a patient's body.

"FIG. 12 shows a side view of the heart treatment device of FIG. 11 treating a heart.

"FIG. 13 shows another example heart treatment device for treating a heart from outside the patient's body.

"FIG. 14 shows a side view of the heart treatment device of FIG. 13 treating a heart.

"FIGS. 15-17 are flow diagrams showing example methods of treating a heart in accordance with the present disclosure."

For additional information on this patent application, see: NAU, JR., WILLIAM H. Device and Method for Salvaging Myocardium following Heart Attack. Filed October 15, 2013 and posted June 5, 2014. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=1419&p=29&f=G&l=50&d=PG01&S1=20140529.PD.&OS=PD/20140529&RS=PD/20140529

Keywords for this news article include: Biotechnology, Ischemia, Peptides, Proteins, Cardiology, Amino Acids, Reperfusion, Gene Therapy, Heart Attack, Bioengineering, Medical Devices, Blood Transfusion, Transfusion Medicine.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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