News Column

Researchers Submit Patent Application, "Bio-Sensor", for Approval

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- From Washington, D.C., NewsRx journalists report that a patent application by the inventors CHO, Chul-Ho (Seongnam-si, KR); CHO, Jae-Geol (Yongin-si, KR), filed on August 14, 2013, was made available online on June 5, 2014 (see also Samsung Electronics Co. Ltd.).

The patent's assignee is Samsung Electronics Co. Ltd.

News editors obtained the following quote from the background information supplied by the inventors: "Generally, in a test that requires a liquid sample for clinical and environmental monitoring, most sensors used for measurement and analysis preferably have small sample capacity. A small sample capacity is required to allow accurate arrival in a measuring device in which a reaction occurs.

"For example, there is increasing need to periodically measure the amount of glucose in the blood (blood sugar) in the diagnosis and prevention of diabetes. Such blood sugar may be easily measured using a blood sugar measuring device that collects a sample from a patient using a bio-sensor in the form of a blood sugar strip. The blood sugar measuring device measures a blood sugar value using an electric signal generated through an electro-chemical reaction between the collected sample and a chemical material in the bio-sensor.

"The bio-sensor is an electrode system including a plurality of electrodes on an insulating substrate formed by a method such as printing an enzyme reaction layer composed of a hydrophilic high-polymer, oxidoreductase, and an electronic acceptor on the formed electrode system.

"Once a sample that includes glucose is injected into the enzyme reaction layer through a sample injection port of the bio-sensor, the enzyme reaction layer dissolves the sample and an enzyme of the sample reacts with the enzyme reaction layer to oxidize the glucose, such that an electronic acceptor is reduced.

"By measuring an oxidation current acquired by electro-chemical oxidization of the reduced electronic acceptor, the concentration of the glucose in the sample may be obtained.

"In the bio-sensor, a sufficient sample is required for the reaction and must be filled in an accurately fixed area. To this end, the bio-sensor usually uses a structure in which a narrow flow path is formed to induce a capillary action.

"Such a bio-sensor 1 includes a lower substrate 2 having electrodes 2a, an intermediate substrate 3 including a sample injection portion 3a, and an upper substrate 4, as illustrated in FIG. 1.

"FIG. 1 is an exploded perspective view of a bio-sensor according to the related art.

"A three-dimensional (3D) shape of the bio-sensor 1 is mostly a rectangular parallelepiped in the shape of '|' or '-'. A user injects a sample into the sample injection portion provided at an end portion to guide the flow of the sample into the bio-sensor.

"As such, an example of the sample injection portion of the bio-sensor may be classified into a '|'-shape type and a '-'-shape type.

"The foregoing two types of sample injection portions are structured such that a tip portion of a straight-line sample injection port is perforated to form a capillary tube. A required blood volume of the blood sugar measuring strip is less than 1 .mu.l, and if this volume of blood is collected from a fingertip, the blood takes the form of a droplet having a diameter of about 2 mm. The capillary tube shape is a rectangular parallelepiped with a width and a length in millimeter range, but a height of 100 .mu.m. Thus, it is not easy for a patient to accurately inject a droplet having a diameter of about 2 mm into a fixed cross-sectional area having a width of 3 mm or less and a height of 100 .mu.m. If the sample is not correctly injected, the user's blood may be collected several times. Moreover, the blood sugar strip may be contaminated and, thus, has to be discarded.

"That is, as the size of the capillary tube of the sample injection port increases, more blood is required to fill the capillary tube, which may not be pleasant to the user. As a result, a conventional blood sugar strip has been designed and manufactured to minimize required blood volume by reducing the size of the capillary tube. Although the required sample volume is reduced because the size of the capillary tube is reduced, the injection position and the shape of the sample injection portion are also reduced in size, thereby making it difficult for the user to inject the sample into the size-reduced sample injection portion.

"Therefore, to overcome the foregoing problem, there is a need for a separate sample injection portion that is larger than a conventional sample injection portion to improve the injection of a small-volume sample.

"The above information is presented as background information only to assist with an understanding of the present disclosure. No determination has been made, and no assertion is made, as to whether any of the above might be applicable as prior art with regard to the present disclosure."

As a supplement to the background information on this patent application, NewsRx correspondents also obtained the inventors' summary information for this patent application: "Aspects of the present disclosure are to address at least the above-mentioned problems and/or disadvantages and to provide at least the advantages described above.

"Accordingly, various aspects of the present disclosure provide a bio-sensor in which a second sample injection portion is formed larger than a sample inlet of a first sample injection portion, facilitating sample injection into a device through a larger sample injection portion and increasing successful sample injection, thus preventing the inconvenience of multiple sample collection attempts and also preventing contamination of the device.

"Other objects to be provided in the present disclosure may be understood by various embodiments described below.

"According to an aspect of the present disclosure, a bio-sensor configured with a lower substrate including a plurality of electrode portions, an insulating layer, a spacer layer, and an upper substrate provided on the spacer layer is provided. The bio-sensor includes a first sample injection portion provided between the upper substrate and the lower substrate along a longitudinal direction in which a sample is introduced and a second sample injection portion that is connected with the first sample injection portion in a direction substantially perpendicular to the longitudinal direction, and formed larger than a sample inlet of the first sample injection portion.

"Other aspects, advantages, and salient features of the disclosure will become apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the annexed drawings, discloses various embodiments of the present disclosure.


"The above and other aspects, features and advantages of certain various embodiments of the present disclosure will be more apparent from the following description taken in conjunction with the accompanying drawings, in which:

"FIG. 1 is an exploded perspective view of a bio-sensor according to the related art;

"FIG. 2 is an exploded perspective view of a bio-sensor according to an embodiment of the present disclosure;

"FIG. 3 is a perspective view illustrating an assembly state of a bio-sensor according to an embodiment of the present disclosure;

"FIG. 4 is a top view illustrating a state before a bio-sensor operates according to an embodiment of the present disclosure;

"FIG. 5 is a top view illustrating an operating process of a bio-sensor according to an embodiment of the present disclosure; and

"FIG. 6 is a top view illustrating a state after a bio-sensor operates according to an embodiment of the present disclosure.

"Throughout the drawings, like reference numerals will be understood to refer to like parts, components, and structures."

For additional information on this patent application, see: CHO, Chul-Ho; CHO, Jae-Geol. Bio-Sensor. Filed August 14, 2013 and posted June 5, 2014. Patent URL:

Keywords for this news article include: Enzymes and Coenzymes, Samsung Electronics Co. Ltd.

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Source: Life Science Weekly

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