By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Biomedicine and Biomedical Engineering. According to news reporting out of Ahvaz, Iran, by NewsRx editors, research stated, "Microenvironmental cues, such as surface topography and substrate stiffness, may affect stem cells adhesion, morphology, alignment, proliferation and differentiation. Adipose derived stem cells (ASCs) have attracted considerable interest in regenerative medicine due to their easy isolation, extensive in vitro expandability and ability to differentiate along a number of different tissue-specific lineages."
Our news journalists obtained a quote from the research from Ahvaz Jundishapur University, "The aim of this work was to investigate ASCs adhesion, alignment and differentiation into myogenic lineage on nanofibrous polymeric scaffolds with anisotropic topography. Nanostructured scaffolds with randomized or parallel fibers were fabricated by electrospinning using polycaprolactone (PCL) and the polycarbonate-urethane ChronoFlex AL 80A (CFAL). Cells expressed myosin (fast skeletal) and tropomyosin in all surface topographies 7 days after seeding but myotube formation was only observed on CFAL scaffolds and only few myotubes were formed on PCL scaffolds."
According to the news editors, the research concluded: "The different cell behavior could be ascribed to two main parameters: fibers dimensions and fibers orientation of the substrates that could result in a better myotube formation on CFAL scaffolds."
For more information on this research see: Adipose-derived stem cells could sense the nano-scale cues as myogenic-differentiating factors. Journal of Materials Science Materials In Medicine, 2013;24(10):2439-47 (see also Biomedicine and Biomedical Engineering).
Our news journalists report that additional information may be obtained by contacting V. Bayati, Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Additional authors for this research include L. Altomare, M.C. Tanzi and S. Fare.
Keywords for this news article include: Iran, Asia, Tissue Engineering, Biomedicine and Biomedical Engineering, Ahvaz, Bioengineering.
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