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Researchers at University of Vienna Release New Data on Molecular Biology

June 17, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Life Science Research is now available. According to news reporting originating in Vienna, Austria, by NewsRx journalists, research stated, "Medicago truncatula has become the focus of systems biology research for improved legume crop breeding. In plant systems biology, several comparative studies have been carried out using liquid chromatography shotgun mass spectrometry (LC-MS/MS) and database-dependent protein identification analyses in combination with the spectral count for relative quantification."

The news reporters obtained a quote from the research from the University of Vienna, "In order to receive optimal protein identification rates and spectral count quantification, data-dependent tandem mass spectrometry with LC separation of more than 1 h is required. Thus LC-MS/MS analyses time is the bottleneck for high-throughput research of experiments with high sample number.We describe a novel method, called full-scan (FS) selective peptide extraction, that allows for comparative quantification of target peptides combined with a significant reduction in LC-MS analysis time. In future, it will be a useful tool to detect (15)N-labeled selected peptide patterns for the targeted analysis of protein turnover and synthesis. We provide a first reference library of selected target peptides generated for M. truncatula leaf tissue."

According to the news reporters, the research concluded: "These peptides are also suitable candidates for selective reaction monitoring approaches."

For more information on this research see: Medicago truncatula proteomics for systems biology: novel rapid shotgun LC-MS approach for relative quantification based on full-scan selective peptide extraction (Selpex). Methods In Molecular Biology, 2014;1072():303-13 (see also Life Science Research).

Our news correspondents report that additional information may be obtained by contacting M.A. Castillejo, Dept. of Molecular Systems Biology, University of Vienna, Vienna, Austria. Additional authors for this research include C. Staudinger, V. Egelhofer and S. Wienkoop.

Keywords for this news article include: Vienna, Europe, Austria, Peptides, Proteins, Amino Acids, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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