News Column

Researchers at Tongji University Report New Data on Drug Delivery Systems

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "Presented in this article is the preparation of a new theranostic vesicle which exhibits excellent in vitro and in vivo T-1 magnetic resonance (MR) imaging contrast effect and good anticancer drug delivery ability. The theranostic vesicle has been easily prepared based on an amphiphilic biocompatible and biodegradable dibock copolymer, poly(ethylene glycol)-block-poly(L-lactic-co-glycolic acid) (PEG-b-PLGA) and bovine serum albumin-gadolinium (BSA-Gd) complexes."

Our news journalists obtained a quote from the research from Tongji University, "Dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES) measurements confirmed the formation and physiological stability of BSA-Gd@PEG-b-PLGA vesicles. Furthermore, the in vitro and in vivo MR imaging experiments revealed their excellent T-1-weighted MR imaging function. Red blood cell hemolysis and cytotoxicity experiments confirmed their good blood compatibility and low cytotoxicity. Doxorubicin (DOX) loading and release experiments indicated a more retarded release rate of DOX in those theranostic vesicles than sole PEG-b-PLGA nanoparticles without BSA."

According to the news editors, the research concluded: "Overall, this new biocompatible and biodegradable vesicle shows promising potential in theranostic applications."

For more information on this research see: Theranostic Vesicles Based on Bovine Serum Albumin and Poly(ethylene glycol)-block-poly(L-lactic-co-glycolic acid) for Magnetic Resonance Imaging and Anticancer Drug Delivery. Biomacromolecules, 2014;15(5):1586-1592. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)

Our news journalists report that additional information may be obtained by contacting Q.M. Liu, Tongji Univ, Sch Med, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Shanghai 200120, People's Republic of China. Additional authors for this research include H.S. Zhu, J.Y. Qin, H.Q. Dong and J.Z. Du (see also Drugs and Therapies).

Keywords for this news article include: Asia, Alkenes, Shanghai, Blood Proteins, Ethylene Glycols, Drugs and Therapies, Acute-Phase Proteins, Bovine Serum Albumin, Drug Delivery Systems, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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