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Researchers at National Institute of Technology Release New Data on DNA Research

June 20, 2014

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on DNA Research. According to news reporting originating in Calicut, India, by NewsRx journalists, research stated, "We demonstrate the amplified detection of BRCAI gene based on the gold nanoparticle labeled DNA sensor. The sensor was based on a 'sandwich' detection strategy, which involved an immobilized capture probe DNA (DNA-c), Target DNA (DNA-t) and gold nanoparticle conjugated reporter probe DNA (DNA-r.AuNP)."

The news reporters obtained a quote from the research from the National Institute of Technology, "The sensor surface was characterized by scanning electron microscopy (SEM) and scanning tunneling microscopy (STM). Detection capability of the sensor was studied with I-V measurements using either scanning tunneling microscopy (STM) or Keithley 2400 Source Meter SMU Instrument. The DNA sensor could detect up to 1 fM DNA target (5.896 fg of BRCA 1 gene/ml) and exhibited excellent selectivity against noncomplementary sequences and three base mismatch complementary targets."

According to the news reporters, the research concluded: "Good reproducibility, high sensitivity, good stability and reusability of the developed sensor surface showed its application in early cancer diagnosis."

For more information on this research see: Femtomolar level detection of BRCA1 gene using a gold nanoparticle labeled sandwich type DNA sensor. Colloids and Surfaces B-Biointerfaces, 2014;117():7-13. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also DNA Research).

Our news correspondents report that additional information may be obtained by contacting P.A. Rasheed, Natl Inst Technol Calicut, Sch Nano Sci & Technol, Nanosci Res Lab, Calicut, Kerala, India.

Keywords for this news article include: Asia, India, BRCA1, Calicut, Genetics, DNA Research, Nanotechnology, Gold Nanoparticles, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Genomics & Genetics Weekly

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