By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Nanotechnology and Microtechnology. According to news originating from Aarhus, Denmark, by NewsRx correspondents, research stated, "Biocatalytic surface coatings are prepared herein for localized synthesis of drugs and their on-demand, site-specific delivery to adhering cells. This novel approach is based on the incorporation of an enzyme into multilayered polymer coatings to accomplish enzyme-prodrug therapy (EPT)."
Our news journalists obtained a quote from the research from Aarhus University, "The build-up of enzyme-containing multilayered coatings is characterized and correlations are drawn between the multilayer film assembly conditions and the enzymatic activity of the resulting coatings. Therapeutic effect elicited by the substrate mediated EPT (SMEPT) strategy is investigated using a prodrug for an anticancer agent, SN-38. The performance of biocatalytic coatings under flow conditions is investigated and it is demonstrated that EPT allows synthesizing the drugs on-demand, at the time desired and in a controllable amount to suit particular applications. Finally, using cells cultured in sequentially connected flow chambers, it is demonstrated that SMEPT affords a site-specific drug delivery, that is, exerts a higher therapeutic effect in cells adhering directly to the biocatalytic coatings than in the cells cultured downstream."
According to the news editors, the research concluded: "Taken together, these data illustrate biomedical opportunities made possible by engineering tools of EPT into multilayered polymer coatings and present a novel, highly versatile tool for surface mediated drug delivery."
For more information on this research see: Biocatalytic Polymer Coatings: On-Demand Drug Synthesis and Localized Therapeutic Effect under Dynamic Cell Culture Conditions. Small, 2014;10(7):1314-1324. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
The news correspondents report that additional information may be obtained from B. Fejerskov, Aarhus University, Interdisciplinary Nanosci Center iNANO, DK-8000 Aarhus, Denmark. Additional authors for this research include N.B.S. Jensen, B.M. Teo, B. Stadler and A.N. Zelikin (see also Nanotechnology and Microtechnology).
Keywords for this news article include: Aarhus, Europe, Denmark, Therapy, Drug Delivery Systems, Enzymes and Coenzymes, Nanotechnology and Microtechnology
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