News Column

Research Data from Taipei Medical University Update Understanding of Platinum Compounds

June 17, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Platinum Compounds have been published. According to news reporting from Taipei, Taiwan, by NewsRx journalists, research stated, "X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications."

The news correspondents obtained a quote from the research from Taipei Medical University, "Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl) acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation."

According to the news reporters, the research concluded: "Finally, the iohexol-cisplatin-gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery."

For more information on this research see: Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging. Journal of Polymer Engineering, 2014;34(3):267-271. Journal of Polymer Engineering can be contacted at: Walter De Gruyter Gmbh, Genthiner Strasse 13, D-10785 Berlin, Germany (see also Platinum Compounds).

Our news journalists report that additional information may be obtained by contacting W.H. Liu, Taipei Medical University, Wan Fang Hosp, Dept. of Dental, Taipei 11696, Taiwan. Additional authors for this research include Y.K. Wang, C.C. Wu, W.P. Deng, K.H. Lin, W.C. Lo and C.L. Tseng.

Keywords for this news article include: Asia, Taipei, Taiwan, Gelatin, Cisplatin, Scleroproteins, Chlorine Compounds, Imaging Technology, Nitrogen Compounds, Platinum Compounds, Computed Tomography

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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