By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Gold Nanoparticles are discussed in a new report. According to news originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Drug delivery systems (DDSs) offer efficient and localized drug transportation as well as reduce associated side effects. In order to better understand DDSs, precise observation of drug release and delivery is required."
Our news journalists obtained a quote from the research from the School of Chemistry and Biochemistry, "Here, we present a strategy, plasmonic-tunable Raman/fluorescence imaging spectroscopy, to track the release and delivery of an anticancer drug (doxorubicin) from gold nanoparticle carriers in real time at a single living cell level. A pH-responsive drug release profile was attained through the conjugation of doxorubicin (DOX) to the nanoparticle surface via a pH-sensitive hydrazone linkage. When DOX is bound to the surface of the gold nanoparticle, its surface-enhanced Raman spectrum can be seen, but its fluorescence is quenched. When released, due to the lysosomes' acidic pH, its Raman enhancement is greatly reduced, changing the acquired Raman spectrum and in turn allowing for the visualization of its fluorescence signal. The plasmonic-tunable Raman/fluorescence properties enabled the tracking of the DOX release and delivery process from the gold nanoparticle surface to the lysosomes of single living cells under the acidic pH change of their microenvironments."
According to the news editors, the research concluded: "This technique offers great potential to follow the molecular mechanisms of drug delivery and release in living cells, as well as the cellular response to drug action."
For more information on this research see: Exploiting the nanoparticle plasmon effect: observing drug delivery dynamics in single cells via Raman/fluorescence imaging spectroscopy. Acs Nano, 2013;7(8):7420-7. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)
The news correspondents report that additional information may be obtained from B. Kang, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-040, United States. Additional authors for this research include M.M. Afifi, L.A. Austin and M.A El-Sayed (see also Gold Nanoparticles).
Keywords for this news article include: Atlanta, Georgia, United States, North and Central America, Antibiotics Antineoplastics, Doxorubicin Hydrochloride, Drugs, Emerging Technologies, Gold Nanoparticles, Nanotechnology, Pharmaceuticals, Therapy.
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