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Reports Summarize Enzymes and Coenzymes Study Results from Singapore Institute of Manufacturing Technology

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Enzymes and Coenzymes have been published. According to news reporting out of Singapore, Singapore, by NewsRx editors, research stated, "Nerve agents are organophosphates which inhibit the function of the acetylcholinesterase (AChE) enzyme in the hydrolysis of neurotransmitter acetylcholine (ACh) in the human nervous system. The microfluidic chip which identifies the presence of nerve agents is designed and developed in this study through electrochemical detection method."

Our news journalists obtained a quote from the research from the Singapore Institute of Manufacturing Technology, "The microfluidic chip integrates immobilized enzyme with screen-printed electrodes (SPEs) for amperometric analysis of by-products created by enzymatic reaction with the analyte. AChE enzyme is immobilized by cross-linking with glutaraldehyde (GA) on bovine serum albumin (BSA) and housed within an enzymatic chamber on the microfluidic chip. The downstream positioned SPE consists of cobalt phthalocyanine (CoPc) mediated carbon working electrode."

According to the news editors, the research concluded: "The flow of acetylthiocholine chloride (ATChCl) substrate through the enzyme chamber undergoes hydrolysis where by-product choline is oxidized at the SPE which is connected to a potentiostat at a constant applied voltage of 0.1 V. As a result, electrochemical measurements of the presented microfluidic biosensor chip shows good repeatability in the obtained amperometric current measurement and feasibility in the use of portable nerve agent detection device as an application."

For more information on this research see: Microfluidics biosensor chip with integrated screen-printed electrodes for amperometric detection of nerve agent. Sensors and Actuators B-Chemical, 2014;198():233-238. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Enzymes and Coenzymes).

Our news journalists report that additional information may be obtained by contacting Y.J. Yoon, Singapore Inst Mfg Technol, Singapore 638075, Singapore. Additional authors for this research include K.H.H. Li, Y.Z. Low, J. Yoon and S.H. Ng.

Keywords for this news article include: Asia, Chemistry, Biosensing, Bioengineering, Electrochemical, Bionanotechnology, Nanobiotechnology, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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