News Column

Reports Summarize DNA Research Findings from Ohio State University

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on DNA Research are discussed in a new report. According to news reporting originating from Columbus, Ohio, by NewsRx correspondents, research stated, "Investigation of single molecule DNA dynamics in confined environments has led to important applications in DNA analysis, separation, and sequencing. Here, we studied the electrophoretic transport of DNA molecules through nanochannels shorter than the DNA contour length and calculated the associated translocation time curves."

Our news editors obtained a quote from the research from Ohio State University, "We found that the longer T4 DNA molecules required a longer time to traverse a fixed length nanochannel than shorter lambda DNA molecules and that the translocation time decreased with increasing electric field which agreed with theoretical predictions. We applied this knowledge to design an asymmetric electric pulse and demonstrate the different responses of lambda and T4 DNA to the pulses. We used Brownian dynamics simulations to corroborate our experimental results on DNA translocation behaviour."

According to the news editors, the research concluded: "This work contributes to the fundamental understanding of polymer transport through nanochannels and may help in designing better separation techniques in the future."

For more information on this research see: DNA translocation through short nanofluidic channels under asymmetric pulsed electric field. Biomicrofluidics, 2014;8(2):243-253. Biomicrofluidics can be contacted at: Amer Inst Physics, Circulation & Fulfillment Div, 2 Huntington Quadrangle, Ste 1 N O 1, Melville, NY 11747-4501, USA. (American Institute of Physics -; Biomicrofluidics -

The news editors report that additional information may be obtained by contacting C. Gupta, Ohio State University, William G Lowrie Dept. of Chem & Biomol Engn, Columbus, OH 43210, United States. Additional authors for this research include W.C. Liao, D. Gallego-Perez, C.E. Castro and L.J. Lee (see also DNA Research).

Keywords for this news article include: Ohio, Columbus, DNA Research, Nanochannels, United States, Nanotechnology, Emerging Technologies, North and Central America

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Source: Life Science Weekly

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