News Column

Reports Outline Cancer Therapy Study Results from Korea Research Institute of Chemical Technology

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- New research on Oncology is the subject of a report. According to news originating from Taejon, South Korea, by NewsRx correspondents, research stated, "Liposome-based drug delivery systems hold great potential for cancer therapy. However, to enhance the localization of payloads, an efficient method of systemic delivery of liposomes to tumor tissues is required."

Our news journalists obtained a quote from the research from the Korea Research Institute of Chemical Technology, "In this study, we developed cationic liposomes composed of polyethylenimine (PEI)-conjugated distearoylglycerophosphoethanolamine (DSPE) as an enhanced local drug delivery system. The particle size of DSPE-PEI liposomes was 130 +/- 10 nm and the zeta potential of liposomes was increased from -25 to 30 mV by the incorporation of cationic PEI onto the liposomal membrane. Intracellular uptake of DSPE-PEI liposomes by tumor cells was 14-fold higher than that of DSPE liposomes. After intratumoral injection of liposomes into tumor-bearing mice, DSPE-PEI liposomes showed higher and sustained localization in tumor tissue compared to DSPE liposomes."

According to the news editors, the research concluded: "Taken together, our findings suggest that DSPE-PEI liposomes have the potential to be used as effective drug carriers for enhanced intracellular uptake and localization of anticancer drugs in tumor tissue through intratumoral injection."

For more information on this research see: Enhanced localization of anticancer drug in tumor tissue using polyethylenimine-conjugated cationic liposomes. Nanoscale Research Letters, 2014;9():1-6. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Nanoscale Research Letters -

The news correspondents report that additional information may be obtained from H.D. Han, Korea Res Inst Chem Technol, Res Center Med Chem, Div Drug Discovery Res, Taejon 305600, South Korea. Additional authors for this research include Y. Byeon, H.N. Jeon and B.C. Shin (see also Oncology).

Keywords for this news article include: Asia, Taejon, Therapy, Oncology, South Korea, Drug Delivery Systems

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Source: Biotech Week

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