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Reports on Atherosclerosis Findings from University of Western Ontario Provide New Insights

June 16, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators discuss new findings in Cardiovascular Diseases and Conditions. According to news reporting originating in London, Canada, by NewsRx journalists, research stated, "The underlying cause of major cardiovascular events, such as myocardial infarctions and strokes, is atherosclerosis. For accurate diagnosis of this inflammatory disease, molecular imaging is required."

The news reporters obtained a quote from the research from the University of Western Ontario, "Toward this goal, we sought to develop a nanoparticle-based, high aspect ratio, molecularly targeted magnetic resonance (MR) imaging contrast agent. Specifically, we engineered the plant viral nanoparticle platform tobacco mosaic virus (TMV) to target vascular cell adhesion molecule (VCAM)-1, which is highly expressed on activated endothelial cells at atherosclerotic plaques. To achieve dual optical and MR imaging in an atherosclerotic ApoE(-/-) mouse model, TMV was modified to carry near-infrared dyes and chelated Gd ions. Our results indicate molecular targeting of atherosclerotic plaques."

According to the news reporters, the research concluded: "On the basis of the multivalency and multifunctionality, the targeted TMV-based MR probe increased the detection limit significantly; the injected dose of Gd ions could be further reduced 400x compared to the suggested clinical use, demonstrating the utility of targeted nanoparticle cargo delivery."

For more information on this research see: Dual-Modal Magnetic Resonance and Fluorescence Imaging of Atherosclerotic Plaques in Vivo Using VCAM-1 Targeted Tobacco Mosaic Virus. Nano Letters, 2014;14(3):1551-1558. Nano Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Nano Letters -

Our news correspondents report that additional information may be obtained by contacting M.A. Bruckman, University of Western Ontario, Dept. of Chem, London, ON N6A 4L6, Canada. Additional authors for this research include K. Jiang, E.J. Simpson, L.N. Randolph, L.G. Luyt, X. Yu and N.F. Steinmetz (see also Cardiovascular Diseases and Conditions).

Keywords for this news article include: London, Canada, Ontario, Virology, Cardiology, RNA Viruses, Plant Viruses, Mosaic Viruses, Atherosclerosis, North and Central America, Cardiovascular Diseases and Conditions

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Source: Cardiovascular Week

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