News Column

Reports from Nanjing Medical University Add New Data to Findings in Nanoparticles

June 20, 2014

By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Nanoparticles are presented in a new report. According to news reporting out of Nanjing, People's Republic of China, by NewsRx editors, research stated, "Acetylshikonin (AS) has demonstrated antitumor potential. However, the development of therapeutic applications utilizing AS is inhibited by its poor solubility in water."

Our news journalists obtained a quote from the research from Nanjing Medical University, "In the present work, polyamidoamine (PAMAM) dendrimers and their PEGylated derivatives were employed to increase the solubility of AS. A distinct color transition was observed during the encapsulation of AS suggesting strong intermolecular forces between PAMAM and AS. Ultraviolet-visible, high-performance liquid chromatography, and (1)H NMR were used to verify the interaction between PAMAM and AS. The maximum amount of combined AS to each PAMAM molecule was determined."

According to the news editors, the research concluded: "The cytotoxicity of AS nanoparticles was evaluated against leukemia (K562) and breast cancer (SK-BR-3) cell lines; the AS nanoparticles were shown to effectively inhibit tumor cells."

For more information on this research see: Encapsulation of acetylshikonin by polyamidoamine dendrimers for preparing prominent nanoparticles. Aaps Pharmscitech [electronic Resource], 2014;15(2):425-33. Aaps Pharmscitech [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Nanoparticles).

Our news journalists report that additional information may be obtained by contacting J. Peng, Dept. of Cell Biology, Nanjing Medical University, Nanjing, 210029, People's Republic of China. Additional authors for this research include W. Zhou, X. Xia, X. Qi, L. Sun, M. Wang, Z. Wu and Z. Li.

Publisher contact information for the journal Aaps Pharmscitech [electronic Resource] is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Asia, Nanjing, Nanotechnology, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Drug Week

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