News Column

Reports from E. Moysan and Co-Researchers Add New Data to Findings in Gemcitabine Therapy

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting originating in Angers, France, by NewsRx journalists, research stated, "A new method to form a nanoparticle-structured hydrogel is reported; it is based on the drug being loaded into the nanoparticles to form a solid structure. A lipophilic form of gemcitabine (modified lauroyl), an anti-cancer drug, was encapsulated in lipid nanocapsules (LNCs), using a phase-inversion temperature process."

The news reporters obtained a quote from the research, "A gel was formed spontaneously, depending on the LNC concentration. The drug loading, measured with total entrapment efficiency, and the rheological properties of the gel were assessed. Physical studies (surface tension measurements) showed that modified gemcitabine was localised at the oil-water interface of the LNC, and that the gemcitabine moieties of the prodrug were exposed to the water phase. This particular assembly promoted inter-LNC interactions via hydrogen bonds between gemcitabine moieties that led to an LNC gel structure in water, without a matrix, like a tridimensional pearl necklace. Dilution of the gel produced a gemcitabine-loaded LNC suspension in water, and these nanoparticles presented cytotoxic activity to various cancer cell lines to a greater degree than the native drug."

According to the news reporters, the research concluded: "Finally, the syringeability of the formulation was successfully tested and perspectives of its use as a nanomedicine (intratumoural or subcutaneous injection) can be foreseen."

For more information on this research see: An innovative hydrogel of gemcitabine-loaded lipid nanocapsules: when the drug is a key player of the nanomedicine structure. Soft Matter, 2014;10(11):1767-77. (Royal Society of Chemistry -; Soft Matter -

Our news correspondents report that additional information may be obtained by contacting E. Moysan, LUNAM Universite - Micro et Nanomedecines Biomimetiques, Universite d'Angers - UMR_S1066 (MINT), IBS-CHU Angers, 4 rue Larrey, F-49933 Angers, France. Additional authors for this research include Y. Gonzalez-Fernandez, N. Lautram, J. Bejaud, G. Bastiat and J.P Benoit (see also Drugs and Therapies).

Keywords for this news article include: Antimetabolites, Antineoplastics, Antivirals, Angers, France, Europe, Alcohols, Hydrogel, Gemcitabine, Nanoparticle, Nanotechnology, Organic Chemicals, Drugs and Therapies, Polyethylene Glycols, Emerging Technologies, Immunosuppressive Agents, Radiation Sensitizing Agents.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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