News Column

Recent Studies from School of Medicine Add New Data to Investigative Ophthalmology and Visual Science

June 20, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Ophthalmology. According to news reporting out of Singapore, Singapore, by NewsRx editors, research stated, "Macular diseases may be associated with an altered retinal vasculature. We describe and test new software for the measurement of retinal vascular fractal dimension to quantify the complexity of retinal vasculature at the macula (D-mac) and to compare this with fractal dimension measured around the optic disc (D-disc)."

Our news journalists obtained a quote from the research from the School of Medicine, "A total of 342 macular-centered and optic disc-centered digital retinal photographs from 171 subjects was selected randomly from a population-based study. Retinal vascular fractional dimension (D-f) was measured by two trained graders using a computer-assisted program (SIVA-FA, software version 1.0, National University of Singapore) on macula-centered (D-mac) and optic disc-centered (D-disc) photographs, to assess intergrader reliability. Measurements were repeated after two weeks to determine intragrader reliability. A separate 50 pairs of consecutively repeated images were selected and measured using SIVA-FA to assess intrasession reliability. Reliability analyses were conducted using intraclass correlation coefficients (ICC), and multiple linear regression analyses were performed to compare factors associated with D-mac and D-disc measurements. The mean (SD) D-mac and D-disc values were 1.453 (0.060) and 1.484 (0.043), respectively, and were highly correlated (r = 0.70, P< 0.001). Intragrader, intergrader, and intrasession reliability for both D-f measures was high (ICCs ranging from 0.88-0.99). In multiple regression analyses, age (both beta = -0.03, P< 0.001) and hypertension (beta = -0.02, P = 0.011; beta = -0.02, P = 0.021, respectively) were independently associated with D-mac and D-disc."

According to the news editors, the research concluded: "The complexity of the retinal vasculature in the macula can be measured reliably and may be a useful tool to study parafoveal vascular networks in macula diseases, such as diabetic maculopathy."

For more information on this research see: Measurement of Macular Fractal Dimension Using a Computer-Assisted Program. Investigative Ophthalmology & Visual Science, 2014;55(4):2237-2243. Investigative Ophthalmology & Visual Science can be contacted at: Assoc Research Vision Ophthalmology Inc, 12300 Twinbrook Parkway, Rockville, MD 20852-1606, USA. (The Association for Research in Vision and Ophthalmology -; Investigative Ophthalmology & Visual Science -

Our news journalists report that additional information may be obtained by contacting G.N. Thomas, Duke NUS Grad Med Sch, Off Clin Sci, Singapore, Singapore. Additional authors for this research include S.Y. Ong, Y.C. Tham, W. Hsu, M.L. Lee, Q.P. Lau, W.T. Tay, J. Alessi-Calandro, L. Hodgson, R. Kawasaki, T.Y. Wong and C.Y. Cheung (see also Ophthalmology).

Keywords for this news article include: Asia, Software, Computers, Ophthalmology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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