By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Lodz, Poland, by NewsRx journalists, research stated, "In this work, we compared two methods (incipient wetness and melting) for the encapsulation of ibuprofen in the pores of Mobil Crystalline Material 41 (MCM-41) through NMR (nuclear magnetic resonance) spectroscopy. H-1 NMR spectra were recorded under very fast MAS (sample spinning 60 kHz) conditions in both ID and 2D mode (NOESY sequence)."
The news correspondents obtained a quote from the research from the Polish Academy of Sciences, "We also performed C-13 cross-polarization magic angle spinning (CP/MAS) experiments, C-13 single pulse experiments (SPE), and H-1-C-13 HSQC HR/MAS (heteronuclear single quantum coherence high resolution) HR/MAS correlations. Evaluation of the encapsulation methods included an analysis of the filling factor of the drug into the pores. The stability of Ibu/MCM in an environment of ethanol or water vapor was tested. Our study showed that melting a mixture of Ibu and MCM is a much more efficient method of confining the drug in the pores compared to incipient wetness. The optimal experiments for the former method achieved a filling factor of approximately 60%. We concluded that the major limitation to the applicability of the incipient wetness method (filling factor ca. 20%) is the high affinity of solvent (typically ethanol) for MCM-41. We found that even ethanol vapor can remove Ibu from the pores. When a sample of Ibu/MCM was stored for a few hours in a closed vessel with ethanol vapor, Ibu was transported from the pores to the outer walls of MCM. We observed a similar phenomenon with water vapor, although this process is slower compared to the analogous procedure using ethanol."
According to the news reporters, the research concluded: "Our study clearly demonstrates that existing methods used to encapsulate drugs in mesoporous silica nanoparticles (MSNs) require reevaluation."
For more information on this research see: Ibuprofen in Mesopores of Mobil Crystalline Material 41 (MCM-41): A Deeper Understanding. Molecular Pharmaceutics, 2014;11(5):1512-1519. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)
Our news journalists report that additional information may be obtained by contacting E. Skorupska, Polish Academy Sci, Center Mol & Macromol Studies, PL-90363 Lodz, Poland. Additional authors for this research include A. Jeziorna, P. Paluch and M.J. Potrzebowski (see also Drugs and Therapies).
Keywords for this news article include: Lodz, Pharmaceuticals, Poland, Europe, Ibuprofen, Phenylpropionates, Drugs and Therapies
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