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Recent Findings in DNA Research Described by Researchers from Shaanxi Normal University

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in DNA Research. According to news reporting originating from Xi'an, People's Republic of China, by NewsRx correspondents, research stated, "A highly sensitive sandwich DNA detection method based on voltammetric detection of thionine-capped gold nanoparticle (AuNP)/reporter DNA conjugate tags on gold particle-modified screen-printed carbon electrode (SPCE) was developed. The SPCE was modified with gold particle by electrodeposition of gold on SPCE surface."

Our news editors obtained a quote from the research from Shaanxi Normal University, "The DNA sensor was prepared by self-assembly of a thiolated DNA probe on gold particle-modified SPCEs. The sandwich-type system was formed by specific recognition of biosensor surface-confined probe DNA to target DNA, followed by attachment of thionine-capped AuNPs/reporter DNA conjugates. The biosensor is very sensitive because of the large number of electroactive thionine molecules in the thionine-capped AuNPs/reporter DNA conjugates. Under optimal conditions, the dynamic detection range of target DNA was from 1.0x10(-16) to 1.0x10(-14) mol L-1, and the detection limit was 0.5x10(-16) mol L-1."

According to the news editors, the research concluded: "The DNA sensor exhibited selectivity against single-base mismatched DNA."

For more information on this research see: Highly sensitive voltammetric detection of DNA hybridization in sandwich format using thionine-capped gold nanoparticle/reporter DNA conjugates as signal tags. Gold Bulletin, 2014;47(1-2):119-125. Gold Bulletin can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Gold Bulletin - www.springerlink.com/content/0017-1557/)

The news editors report that additional information may be obtained by contacting X.H. Liu, Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, People's Republic of China. Additional authors for this research include R. Zhang, X.Q. Yuan, L. Liu, Y.Y. Zhou and Q. Gao (see also DNA Research).

Keywords for this news article include: Asia, Xi'an, Biosensing, DNA Research, Bioengineering, Bionanotechnology, Nanobiotechnology, Gold Nanoparticles, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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