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New Osteosarcomas Study Findings Have Been Reported by Researchers at Xiamen University

June 19, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Oncology. According to news originating from Zhangzhou, People's Republic of China, by NewsRx correspondents, research stated, "Recently, a member of the voltage-dependent potassium channel (Kv) family, the Ether a go-go 1 (Eag1) channel was found to be necessary for cell proliferation, cycle progression and tumorigenesis. However, the therapeutic potential of the Eag1 channel in osteosarcoma remains elusive."

Our news journalists obtained a quote from the research from Xiamen University, "In the present study, a recombinant adenovirus harboring shRNA against Eag1 was constructed to silence Eag1 expression in human osteosarcoma MG-63 cells. We observed that Eag1-shRNA inhibited the proliferation and colony formation of MG-63 cells due to the induction of G1 phase arrest. Moreover, in vivo experiments showed that Eag1-shRNA inhibited osteosarcoma growth in a xenograft nude mice model. In addition, selective inhibition of Eag1 significantly decreased the expression levels of cyclin D1 and E."

According to the news editors, the research concluded: "Taken together, our data suggest that the Eag1 channel plays a crucial role in regulating the proliferation and cell cycle of osteosarcoma cells, and represents a new and effective therapeutic target for osteosarcoma."

For more information on this research see: Silencing of Ether a go-go 1 by shRNA inhibits osteosarcoma growth and cell cycle progression. International Journal of Molecular Sciences, 2014;15(4):5570-81 (see also Oncology).

The news correspondents report that additional information may be obtained from J. Wu, Dept. of Orthopaedics, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, People's Republic of China. Additional authors for this research include D. Zhong, X. Fu, Q. Liu, L. Kang and Z. Ding.

Keywords for this news article include: Asia, Biotechnology, Oncology, Zhangzhou, Orthopedics, Gene Therapy, Osteosarcoma, Therapeutics, Bioengineering, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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