News Column

New Nanocrystals Findings Reported from Virginia Tech

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Nanocrystals have been published. According to news reporting originating from Blacksburg, Virginia, by NewsRx correspondents, research stated, "Elongated nanoparticles have recently been shown to have distinct advantages over spherical ones in targeted drug delivery applications. In addition to their oblong geometry, their lack of cytotoxicity and numerous surface hydroxyl groups make cellulose nanocrystals (CNCs) promising drug delivery vectors."

Our news editors obtained a quote from the research from Virginia Tech, "Herein we report the synthesis of folic acid-conjugated CNCs for the targeted delivery of chemotherapeutic agents to folate receptor-positive cancer cells. Folate receptor-mediated cellular binding/uptake of the conjugate was demonstrated on human (DBTRG-05MG, H4) and rat (C6) brain tumor cells. Folate receptor expression of the cells was verified by immunofluorescence staining. Cellular binding/uptake of the conjugate by DBTRG-05MG, H4, and C6 cells was 1452, 975, and 46 times higher, respectively, than that of nontargeted CNCs. The uptake mechanism was determined by preincubation of the cells with the uptake inhibitors chlorpromazine or genistein."

According to the news editors, the research concluded: "DBTRG-05MG and C6 cells internalized the conjugate primarily via caveolae-mediated endocytosis, whereas H4 cells internalized the conjugate primarily via clathrin-mediated endocytosis."

For more information on this research see: Synthesis and Cellular Uptake of Folic Acid-Conjugated Cellulose Nanocrystals for Cancer Targeting. Biomacromolecules, 2014;15(5):1560-1567. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)

The news editors report that additional information may be obtained by contacting S.P. Dong, Virginia Technical, Dept. of Sustainable Biomat, Blacksburg, VA 24061, United States. Additional authors for this research include H.J. Cho, Y.W. Lee and M. Roman (see also Nanocrystals).

Keywords for this news article include: Pharmaceuticals, Cancer, Therapy, Virginia, Oncology, Blacksburg, Folic Acid, United States, Nanotechnology, Drug Delivery Systems, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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