News Column

New Iron-Binding Proteins Study Results Reported from University of Georgia

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- A new study on Proteins is now available. According to news reporting originating in Athens, Georgia, by NewsRx journalists, research stated, "Photodynamic therapy is an emerging treatment modality that is under intensive preclinical and clinical investigations for many types of disease including cancer. Despite the promise, there is a lack of a reliable drug delivery vehicle that can transport photosensitizers (PSs) to tumors in a site-specific manner."

The news reporters obtained a quote from the research from the University of Georgia, "Previous efforts have been focused on polymer-or liposome-based nanocarriers, which are usually associated with a suboptimal PS loading rate and a large particle size. We report herein that a RGD4C-modified ferritin (RFRT), a protein-based nanoparticle, can serve as a safe and efficient PS vehicle. Zinc hexadecafluorophthalocyanine (ZnF16Pc), a potent PS with a high (1)O2 quantum yield but poor water solubility, can be encapsulated into RFRTs with a loading rate as high as ~60 wt % (i.e., 1.5 mg of ZnF16Pc can be loaded on 1 mg of RFRTs), which far exceeds those reported previously. Despite the high loading, the ZnF16Pc-loaded RFRTs (P-RFRTs) show an overall particle size of 18.6 2.6 nm, which is significantly smaller than other PS-nanocarrier conjugates. When tested on U87MG subcutaneous tumor models, P-RFRTs showed a high tumor accumulation rate (tumor-to-normal tissue ratio of 26.82 4.07 at 24 h), a good tumor inhibition rate (83.64% on day 12), as well as minimal toxicity to the skin and other major organs."

According to the news reporters, the research concluded: "This technology can be extended to deliver other metal-containing PSs and holds great clinical translation potential."

For more information on this research see: Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. Acs Nano, 2013;7(8):6988-96. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

Our news correspondents report that additional information may be obtained by contacting Z. Zhen, Dept. of Chemistry, Bio-Imaging Research Center, University of Georgia, Athens, Georgia 30602, United States. Additional authors for this research include W. Tang, C. Guo, H. Chen, X. Lin, G. Liu, B. Fei, X. Chen, B. Xu and J. Xie (see also Proteins).

Keywords for this news article include: Biotechnology, Athens, Cancer, Georgia, Oncology, Ferritins, Phototherapy, United States, Photodynamic Therapy, Iron Binding Proteins, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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