News Column

New Immunologic Receptors Study Results Reported from I. Debergh et al

June 20, 2014

By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Membrane Proteins. According to news reporting out of Paris, France, by NewsRx editors, research stated, "The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe targeting alpha(v)beta(3) integrin."

Our news journalists obtained a quote from the research, "HT29 human colorectal cancers were grown in athymic mice. Dynamic MRI was performed using a three-dimensional VIBE sequence up to 110 min after injection of P1227 or gadolinium-tetraazacyclododecane tetraacetic acid (Gd-DOTA). Specificity was assessed by using P1227 1 h after intravenous administration of the alpha(v)beta(3) inhibitor cilengitide. Regions of interest were drawn encompassing the tumor rim and normal muscle. Imaging data were compared with microvessel density and alpha(v)beta(3) expression. Using P1227, specific enhancement of the angiogenic tumor rim, but not of normal muscle, was observed, whereas Gd-DOTA enhanced tumor and normal muscle. After administering cilengitide, enhancement with P1227, but not with DOTA, was significantly suppressed during the first 20 min. When using P1227, a significant correlation was observed between normalized enhancement of the tumor rim and immunohistochemical alpha(v)beta(3) integrin expression."

According to the news editors, the research concluded: "Molecular MRI using a small monogadolinated tracer targeting alpha(v)beta(3) integrin and moderate magnetic field strength holds promise in assessing colorectal TAA."

For more information on this research see: Molecular Imaging of Tumor-Associated Angiogenesis Using a Novel Magnetic Resonance Imaging Contrast Agent Targeting alpha(v)beta(3) Integrin. Annals of Surgical Oncology, 2014;21(6):2097-2104. Annals of Surgical Oncology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Annals of Surgical Oncology -

Our news journalists report that additional information may be obtained by contacting I. Debergh, Guerbet Res, Paris, France. Additional authors for this research include N. Van Damme, D. De Naeyer, P. Smeets, P. Demetter, P. Robert, S. Carme, P. Pattyn and W. Ceelen (see also Membrane Proteins).

Keywords for this news article include: Paris, France, Europe, Therapy, Integrins, Angiogenesis, Nanotechnology, Membrane Proteins, Molecular Imaging, Magnetic Resonance, Emerging Technologies, Immunologic Receptors

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Source: Angiogenesis Weekly

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