By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanotechnology and Microtechnology is the subject of a report. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "Functionalized fluorescent dyes have attracted great interest for the specific staining of subcellular organelles in multicellular organisms. A novel nanometer-sized water-soluble multi-functional squarylium indocyanine dye (D1) that contains four primary amines is synthesized."
Our news journalists obtained a quote from the research from China Agricultural University, "The dye exhibits good photostability, non-toxicity and biocompatibility. Isothermal titration calorimetry demonstrates that an affinity between D1 and DNA is higher than that between D1 and analogue of phospholipids. Analysis of circular dichroism spectra indicates that D1 targets to the DNA minor groove and aggregates to a helix. Because of the distinct affinity between the dye and subcellular organelles, the dye exhibits difunctional abilities to label the cell nuclei in fixed cells/tissue and the cell membranes in live cells/tissue. By combination of the two staining capabilities, the dye is further explored as a specific marker to distinguish apoptotic cells in live cells/tissue."
According to the news editors, the research concluded: "The research opens a new way to design novel multifunctional dyes for life science applications."
For more information on this research see: A Difunctional Squarylium Indocyanine Dye Distinguishes Dead Cells through Diverse Staining of the Cell Nuclei/Membranes. Small, 2014;10(7):1351-1360. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
Our news journalists report that additional information may be obtained by contacting J. Li, China Agricultural University, Dept. of Entomol, Beijing 100193, People's Republic of China. Additional authors for this research include K.R. Guo, J. Shen, W.T. Yang and M.Z. Yin (see also Nanotechnology and Microtechnology).
Keywords for this news article include: Asia, Beijing, People's Republic of China, Nanotechnology and Microtechnology
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