News Column

New Findings on DNA Research Discussed by Researchers at Center for Nanoscience

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on DNA Research is now available. According to news originating from Munich, Germany, by NewsRx correspondents, research stated, "The detailed study of protein-DNA interactions is a core effort to elucidate physiological processes, including gene regulation, DNA repair and the immune response. The molecular force assay (MFA) is an established method to study DNA-binding proteins."

Our news journalists obtained a quote from the research from Center for Nanoscience, "In particular, high-affinity binder dissociation is made possible by the application of force. Microfluidic lab-on-a-chip approaches have proven helpful for parallelization, small sample volumes, reproducibility, and low cost. We report the successful combination of these two principles, forming a microfluidic molecular force assay and representing a novel use for the established MITOMI chip design. We present, characterize, validate and apply this integrated method. An alternative confocal fluorescence microscopy readout and analysis method is introduced and validated. In a multiplexing application, EcoRI binding is detected and characterized. This method paves the way for quantitative on-chip force measurements."

According to the news editors, the research concluded: "It is suited for integration with DNA micro-spotting and in vitro expression of transcription factors to form a high-throughput chip for detailed DNA-protein interaction studies."

For more information on this research see: Protein-DNA force assay in a microfluidic format. Lab On a Chip - Miniaturisation for Chemistry and Biology, 2013;13(21):4198-204 (see also DNA Research).

The news correspondents report that additional information may be obtained from M. Otten, Lehrstuhl fur Angewandte Physik and Center for Nanoscience (CeNS), Ludwig-Maximilians-Universitat, Amalienstrasse 54, 80799 Munich, Germany. Additional authors for this research include P. Wolf and H.E Gaub.

Keywords for this news article include: Munich, Europe, Germany, DNA Research.

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Source: Life Science Weekly

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