News Column

New Findings on Coagulation Modifiers from University of Pittsburgh Summarized

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting from Pittsburgh, Pennsylvania, by NewsRx journalists, research stated, "Dabigatran is an oral direct thrombin inhibitor that is Food and Drug Administration-approved for prevention of stroke in patients with atrial fibrillation. No antidote is available for reversal of dabigatran's anticoagulant effect."

The news correspondents obtained a quote from the research from the University of Pittsburgh, "Despite limited clinical data, hemodialysis has been suggested as a strategy to remove dabigatran during acute bleeding. This work presents five cases, in which extracorporeal therapy was performed for dabigatran removal in acutely bleeding patients. The series is comprised of five consecutive cases of patients receiving dabigatran 150 mg per os two times daily who were admitted with life-threatening bleeding between March of 2012 and January of 2013. Dabigatran plasma concentrations ranged from 149 to 1200 ng/ml. Treatment included administration of blood products to all patients and then, high-flux intermittent hemodialysis alone or followed by continuous renal replacement therapy. Dabigatran concentrations decreased by 52%-77% during intermittent hemodialysis but rebounded up to 87% within 2 hours after completion of dialysis. Initiation of continuous renal replacement therapy after intermittent hemodialysis attenuated the rebound effect in one patient and contributed to a reduction in dabigatran concentrations of 81% over 30 hours. Extracorporeal therapy lowered dabigatran concentrations, suggesting that it removed the drug and may effectively accelerate total clearance, especially in patients with impaired kidney function. The use of prolonged intermittent hemodialysis or intermittent hemodialysis followed by continuous renal replacement therapy is recommended for the management of life-threatening bleeding in patients receiving dabigatran."

According to the news reporters, the research concluded: "The advantage of extracorporeal therapy should be weighed against the risk of bleeding with catheter insertion."

For more information on this research see: Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clinical Journal of the American Society of Nephrology, 2013;8(9):1533-9 (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting T. Singh, Renal-Electrolyte Division, Dept. of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States. Additional authors for this research include T.T. Maw, B.L. Henry, N.M. Pastor-Soler, M.L. Unruh, K.R. Hallows and T.D Nolin.

Keywords for this news article include: Anticoagulants, Kidney, Pittsburgh, Dabigatran, Nephrology, Pennsylvania, Hemodialysis, United States, Renal Dialysis, Drugs and Therapies, Thrombin Inhibitors, Coagulation Modifiers, North and Central America, Renal Replacement Therapy.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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