News Column

New Findings from University of Notre Dame in the Area of Cancer Therapy Described

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- New research on Oncology is the subject of a report. According to news reporting from Notre Dame, Indiana, by NewsRx journalists, research stated, "Mesoporous silica nanoparticles (MSN) with 1,2-bidentate carboxyl groups on the surface reacted with 1,2-diaminecyclohexano platinum(II) dinitrate (DACH-Pt-(NO3)2) which is an active anticancer species of clinic relevant oxaliplatin to form MSN-Pt. The modification of the parent particles was monitored by C-13, Si-29 solid-state NMR, X-ray measurements (XRD) and Fourier transform infrared spectroscopy (FT-IR)."

The news correspondents obtained a quote from the research from the University of Notre Dame, "After loading with platinum drugs, MSN-Pt exhibited two strong Pt-4f signals as indicated by X-ray photoelectron spectroscopy (XPS). The platinum content in the conjugates was calculated to be 9.7% according to ICP-MS measurements. Confocal laser scanning microscopy (CLSM) displayed that MSN-Pt were uptaken fast by HepG-2 cells and concentrated within endosomes and lysosomes. In vitro MU assay of MSN-Pt demonstrated an improved cytotoxicity against HepG-2 cells than that of free oxaliplatin. This is due to the fact that MSN-Pt expressed higher platinum intracellular uptake and more DNA binding (Pt-DNA adducts) than free oxaliplatin."

According to the news reporters, the research concluded: "Hence this work highlighted that the platinum loaded MSN nanoparticles could be a promising future intelligent drug delivery system."

For more information on this research see: Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery. Colloids and Surfaces B-Biointerfaces, 2014;117():75-81. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Oncology).

Our news journalists report that additional information may be obtained by contacting H.Y. He, University of Notre Dame, Dept. of Chem & Biomol Engn, Notre Dame, IN 46556, United States. Additional authors for this research include H.H. Xiao, H.H. Kuang, Z.G. Xie, X.S. Chen, X.B. Jing and Y.B. Huang.

Keywords for this news article include: Indiana, Therapy, Oncology, Notre Dame, Nanoparticle, United States, Nanotechnology, Silicon Nanocrystals, Drug Delivery Systems, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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