News Column

New Findings from Deakin University in Peptides and Proteins Provides New Insights

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteins are discussed in a new report. According to news originating from Geelong, Australia, by NewsRx correspondents, research stated, "Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically."

Our news journalists obtained a quote from the research from Deakin University, "Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility of fabricating pantothenic acid (vitamin B-5, VB5)-reinforcing SF nanofibrous matrices for biomedical applications through green electrospinning. Results demonstrated the successful loading of D-pantothenic acid hemicalcium salt (VB5-hs) into resulting composite nanofibers. The introduction of VB5-hs did not alter the smooth ribbon-like morphology and the silk I structure of SF, but significantly decreased the mean width of SF fibers. SF conformation transformed into beta-sheet from random coil when composite nanofibrous matrices were exposed to 75% (v/v) ethanol vapor. Furthermore, nanofibers still remained good morphology after being soaked in water environment for five days. Interestingly, as-prepared composite nanofibrous matrices supported a higher level of cell viability, especially in a long culture period and significantly assisted skin cells to survive under oxidative stress compared with pure SF nanofibrous matrices."

According to the news editors, the research concluded: "These findings provide a basis for further extending the application of SF in the biomedical field, especially in the personal skin-care field."

For more information on this research see: Green electrospun pantothenic acid/silk fibroin composite nanofibers: Fabrication, characterization and biological activity. Colloids and Surfaces B-Biointerfaces, 2014;117():14-20. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Proteins).

The news correspondents report that additional information may be obtained from L.P. Fan, Deakin University, Australian Future Fibres Res & Innovat Center, Inst Frontier Mat, Geelong, Vic 3217, Australia. Additional authors for this research include Z.X. Cai, K.H. Zhang, F. Han, J.L. Li, C.L. He, X.M. Mo, X.G. Wang and H.S. Wang.

Keywords for this news article include: Geelong, Proteins, Australia and New Zealand

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Source: Life Science Weekly

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