News Column

New Findings from Biotechnology Research Institute in the Area of Metabolism Reported

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Metabolism have been published. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Although cold shock responses and the roles of cold shock proteins in microorganisms containing multiple cold shock protein genes have been well characterized, related studies on bacteria possessing a single cold shock protein gene have not been reported. Thermoanaerobacter tengcongensis MB4, a thermophile harboring only one known cold shock protein gene (TtescpC), can survive from 50 to 80 C, but has poor natural competence under cold shock at 50 C."

The news correspondents obtained a quote from the research from Biotechnology Research Institute, "We therefore examined cold shock responses and their effect on natural competence in this bacterium. The transcriptomes of T. tengcongensis before and after cold shock were analyzed by RNA-seq and over 1200 differentially expressed genes were successfully identified. These genes were involved in a wide range of biological processes, including modulation of DNA replication, recombination, and repair; energy metabolism; production of cold shock protein; synthesis of branched amino acids and branched-chain fatty acids; and sporulation. RNA-seq analysis also suggested that T. tengcongensis initiates cell wall and membrane remodeling processes, flagellar assembly, and sporulation in response to low temperature. Expression profiles of TtecspC and failed attempts to produce a TtecspC knockout strain confirmed the essential role of TteCspC in the cold shock response, and also suggested a role of this protein in survival at optimum growth temperature. Repression of genes encoding ComEA and ComEC and low energy metabolism levels in cold-shocked cells are the likely basis of poor natural competence at low temperature. Our study demonstrated changes in global gene expression under cold shock and identified several candidate genes related to cold shock in T. tengcongensis. At the same time, the relationship between cold shock response and poor natural competence at low temperature was preliminarily elucidated."

According to the news reporters, the research concluded: "These findings provide a foundation for future studies on genetic and molecular mechanisms associated with cold shock and acclimation at low temperature."

For more information on this research see: RNA-Seq-based analysis of cold shock response in Thermoanaerobacter tengcongensis, a bacterium harboring a single cold shock protein encoding gene. Plos One, 2014;9(3):e93289. (Public Library of Science -; Plos One -

Our news journalists report that additional information may be obtained by contacting B. Liu, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China. Additional authors for this research include Y. Zhang and W. Zhang (see also Metabolism).

Keywords for this news article include: Asia, Beijing, Metabolism, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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