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New Enzymes and Coenzymes Study Findings Have Been Reported by Researchers at College of France

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Enzymes and Coenzymes. According to news reporting out of Paris, France, by NewsRx editors, research stated, "Over the last 15 years, a plethora of research has provided major insights into the structure and function of hydrogenase enzymes. This has led to the important development of chemical models that mimic the inorganic enzymatic co-factors, which in turn has further contributed to the understanding of the specific molecular features of these natural systems that facilitate such large and robust enzyme activities."

Our news journalists obtained a quote from the research from the College of France, "More recently, efforts have been made to generate guest-host models and artificial hydrogenases, through the incorporation of transition metal-catalysts (guests) into various hosts. This adds a new layer of complexity to hydrogenase-like catalytic systems that allows for better tuning of their activity through manipulation of both the first (the guest) and the second (the host) coordination spheres. Herein we review the aforementioned advances achieved during the last 15 years, in the field of inorganic biomimetic hydrogenase chemistry."

According to the news editors, the research concluded: "After a brief presentation of the enzymes themselves, as well as the early bioinspired catalysts, we review the more recent systems constructed as models for the hydrogenase enzymes, with a specific focus on the various strategies employed for incorporating of synthetic models into supramolecular frameworks and polypeptidic/protein scaffolds, and critically discuss the advantages of such an elaborate approach, with regard to the catalytic performances."

For more information on this research see: Mimicking hydrogenases: From biomimetics to artificial enzymes. Coordination Chemistry Reviews, 2014;270():127-150. Coordination Chemistry Reviews can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland. (Elsevier -; Coordination Chemistry Reviews -

Our news journalists report that additional information may be obtained by contacting T.R. Simmons, Coll France, F-75231 Paris 5, France. Additional authors for this research include G. Berggren, M. Bacchi, M. Fontecave and V. Artero (see also Enzymes and Coenzymes).

Keywords for this news article include: Paris, France, Europe, Biomimetics, Bioengineering, Medical Devices, Artificial Enzyme, Bionanotechnology, Nanobiotechnology, Emerging Technologies, Enzymes and Coenzymes

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Source: Biotech Week

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