By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting originating in Amherst, Massachusetts, by NewsRx journalists, research stated, "Intracellular protein delivery is an important tool for both therapeutic and fundamental applications. Effective protein delivery faces two major challenges: efficient cellular uptake and avoiding endosomal sequestration."
The news reporters obtained a quote from the research from the University of Massachusetts, "We report here a general strategy for direct delivery of functional proteins to the cytosol using nanoparticle-stabilized capsules (NPSCs). These NPSCs are formed and stabilized through supramolecular interactions between the nanoparticle, the protein cargo, and the fatty acid capsule interior. The NPSCs are ~130 nm in diameter and feature low toxicity and excellent stability in serum. The effectiveness of these NPSCs as therapeutic protein carriers was demonstrated through the delivery of fully functional caspase-3 to HeLa cells with concomitant apoptosis."
According to the news reporters, the research concluded: "Analogous delivery of green fluorescent protein (GFP) confirmed cytosolic delivery as well as intracellular targeting of the delivered protein, demonstrating the utility of the system for both therapeutic and imaging applications."
For more information on this research see: Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. Acs Nano, 2013;7(8):6667-73. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting R. Tang, Dept. of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States. Additional authors for this research include C.S. Kim, D.J. Solfiell, S. Rana, R. Mout, E.M. Velazquez-Delgado, A. Chompoosor, Y. Jeong, B. Yan, Z.J. Zhu, C. Kim, J.A. Hardy and V.M Rotello (see also Drugs and Therapies).
Keywords for this news article include: Amherst, Cytosol, Peptides, Proteins, Cytoplasm, Amino Acids, Nanocapsules, Massachusetts, United States, Nanotechnology, Drugs and Therapies, Intracellular Fluid, Drug Delivery Systems, Emerging Technologies, North and Central America.
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