Chronic kidney disease (CKD) is a worldwide public health problem that affects 26 million Americans in the U.S., with 600,000 requiring dialysis or kidney transplantation. Despite its prevalence, there are fewer clinical trials for kidney disease than any other common disease. In
For the study, a global
Researchers first analyzed kidney disease progression among all participants during a baseline period of two years. They then examined how this progression predicted subsequent disease progression to the observed 12,344 cases of end-stage renal diseases (ESRD) and 223,944 deaths. The study found that the current serum-creatinine standard used in clinical trials which is associated with a 57% reduction in kidney function carried very high risk - a 32-fold increased risk of ESRD and 3.7-fold increased risk of mortality but only occurred in less than 1% of participants in the two-year baseline period.
In contrast, a 30% decline in kidney function, also measured by serum creatinine levels, occurred in 7% of participants in the two-year baseline period. This was associated with a 5-fold higher risk of end-stage renal disease (ESRD) and 1.8-fold higher risk of mortality. This level of risk is high and yet common and early enough to facilitate testing if new therapies are working.
"Chronic kidney disease is often asymptomatic until it's too late," notes Dr. Coresh. "This new definition will help standardize following patients to determine when their disease progresses significantly enough to elevate risk. This will assist in patient care, research studies and development of new therapies."
The findings were presented by Dr. Coresh at the
Keywords for this news article include: Kidney, Therapy, Nephrology, Drug Development, Disease Attributes, Disease Progression, Pathologic Processes, End Stage Renal Disease, Clinical Trials and Studies, Government Agencies Offices and Entities,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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