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New Data from University of Kaiserslautern Illuminate Findings in RNA Folding

June 18, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Biotechnology are presented in a new report. According to news reporting out of Kaiserslautern, Germany, by NewsRx editors, the research stated, "As catalytically active RNAs, ribozymes can be characterized by kinetic measurements similar to classical enzyme kinetics. However, in contrast to standard protein enzymes, for which reactions can usually be started by mixing the enzyme with its substrate, ribozymes are typically self-cleaving."

Our news journalists obtained a quote from the research from the University of Kaiserslautern, "The reaction has to be initiated by folding the RNA into its active conformation. Thus, ribozyme kinetics are influenced by both folding and catalytic components and often enable indirect observation of RNA folding."

According to the news editors, the research concluded: "Here, I describe how to obtain quantitative ribozyme cleavage data via denaturing polyacrylamide gel electrophoresis (PAGE) of radioactively labeled in vitro transcripts and discuss general considerations for subsequent kinetic analysis."

For more information on this research see: The kinetics of ribozyme cleavage: a tool to analyze RNA folding as a function of catalysis. Methods In Molecular Biology, 2014;1086():209-24 (see also Biotechnology).

Our news journalists report that additional information may be obtained by contacting N. Zingler, Dept. of Molecular Genetics, University of Kaiserslautern, Kaiserslautern, Germany.

Keywords for this news article include: Biotechnology, Europe, Germany, RNA Folding, RNA Research, Kaiserslautern, Medical Devices.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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