News Column

New Cytokines Study Findings Recently Were Reported by Researchers at Faculty of Pharmacy

June 19, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Intercellular Signaling Peptides and Proteins. According to news originating from Helsinki, Finland, by NewsRx correspondents, research stated, "Low molecular weight oligonucleotides have been discovered to have potential use for gene therapy by selectively inhibiting the expression of certain genes. Chemical conjugation of functional peptides to oligonucleotides can introduce desired properties to the oligonucleotides, such as cell-specific delivery, cellular uptake efficiency, and/or intracellular distribution."

Our news journalists obtained a quote from the research from the Faculty of Pharmacy, "In this paper, targeting peptides are conjugated to antisense interleukin-6 via a copper (I) catalyzed alkyne-azide cycloaddition click reaction. A simple and reproducible solution-phase conjugation procedure was investigated. Oligonucleotide-peptide conjugations were characterized by reverse-phase high-pressure liquid chromatography and mass spectrometry."

According to the news editors, the research concluded: "The results show that the targeting peptides can be used for targeting delivery of oligonucleotides using the aforementioned conjugation."

For more information on this research see: Conjugation of peptides to antisense interleukin-6 via click chemistry. Current Medicinal Chemistry, 2014;21(10):1247-54. (Bentham Science Publishers -; Current Medicinal Chemistry -

The news correspondents report that additional information may be obtained from C.F. Wang, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, FI-00014 University of Helsinki, Helsinki, Finland. Additional authors for this research include S. Auriola, J. Hirvonen and H.A Santos (see also Intercellular Signaling Peptides and Proteins).

Keywords for this news article include: Biotechnology, Europe, Finland, Helsinki, Chemicals, Chemistry, Cytokines, Amino Acids, Gene Therapy, Interleukin 6, Bioengineering, Intercellular Signaling Peptides and Proteins.

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Source: Gene Therapy Weekly

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