News Column

New Chemometrics Study Findings Have Been Reported by Investigators at National Organization for Drug Control and Research

June 17, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Chemometrics are presented in a new report. According to news originating from Giza, Egypt, by NewsRx correspondents, research stated, "Linezolid (LIN) is determined in the presence of its alkaline (ALK) and oxidative (OXD) degradation products without preliminary separation based on ultraviolet spectrophotometry using two-way chemometric methods; principal component regression (PCR) and partial least-squares (PLS), and three-way chemometric methods; parallel factor analysis (PARAFAC) and multi-way partial least squares (N-PLS). A training set of mixtures containing LIN, ALK and OXD; was prepared in the concentration ranges of 12-18, 2.4-3.6 and 1.2-1.8 jig mL(-1), respectively according to a multilevel multifactor experimental design."

Our news journalists obtained a quote from the research from National Organization for Drug Control and Research, "The multivariate calibrations were obtained by measuring the zero-order absorbance from 220 to 320 nm using the training set. The validation of the multivariate methods was realized by analyzing their synthetic mixtures. The capabilities of the chemometric analysis methods for the analysis of real samples were evaluated by determination of LIN in its pharmaceutical preparation with satisfactory results. The accuracy of the methods, evaluated through the root mean square error of prediction (RMSEP), was 0.058, 0.026, 0.101 and 0.026 for LIN using PCR, PLS, PARAFAC and N-PLS, respectively. Protolytic equilibria of LIN and its degradation products were evaluated using the corresponding absorption spectra-pH data obtained with PARAFAC. The obtained pK(a) values of LIN, ALK and OXD are 5.70, 8.90 and 6.15, respectively."

According to the news editors, the research concluded: "The results obtained were statistically compared to that of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision."

For more information on this research see: Two and three way spectrophotometric-assisted multivariate determination of linezolid in the presence of its alkaline and oxidative degradation products and application to pharmaceutical formulation. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2014;128():231-242. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England (see also Chemometrics).

The news correspondents report that additional information may be obtained from M.A. Hegazy, Natl Organization Drug Control & Res, Giza, Egypt. Additional authors for this research include M.S. Eissa, O.I. Abd El-Sattar and M. Abd El-Kawy.

Keywords for this news article include: Giza, Egypt, Africa, Machine Learning, Emerging Technologies

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Source: Life Science Weekly

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