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New Cancer Vaccines Study Findings Have Been Reported from University of Georgia

June 16, 2014



By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Fresh data on Immunization are presented in a new report. According to news originating from Athens, Georgia, by NewsRx correspondents, research stated, "One of the limitations for clinical applications of dendritic cell (DC)-based cancer immunotherapy is the low potency in generating tumor antigen specific T cell responses. We examined the immunotherapeutic potential of a mitochondria-targeted nanoparticle (NP) based on a biodegradable polymer and zinc phthalocyanine (ZnPc) photosensitizer (T-ZnPc-NPs)."

Our news journalists obtained a quote from the research from the University of Georgia, "Here, we report that tumor antigens generated from treatment of breast cancer cells with T-ZnPc-NPs upon light stimulation activate DCs to produce high levels of interferon-gamma, an important cytokine considered as a product of T and natural killer cells. The remarkable ex vivo DC stimulation ability of this tumor cell supernatant is a result of an interleukin (IL)-12/IL-18 autocrine effect."

According to the news editors, the research concluded: "These findings contribute to the understanding of how in situ light activation amplifies the host immune responses when NPs deliver the photosensitizer to the mitochondria and open up the possibility of using mitochondria-targeted-NP-treated, light-activated cancer cell supernatants as possible vaccines."

For more information on this research see: Ex vivo programming of dendritic cells by mitochondria-targeted nanoparticles to produce interferon-gamma for cancer immunotherapy. Acs Nano, 2013;7(8):7392-402. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

The news correspondents report that additional information may be obtained from S. Marrache, NanoTherapeutics Research Laboratory, Dept. of Chemistry, University of Georgia, Athens, Georgia 30602, United States. Additional authors for this research include S. Tundup, D.A. Harn and S. Dhar (see also Immunization).

Keywords for this news article include: Antigen Presenting Cells, Athens, Georgia, Oncology, Cytokines, Cytoplasm, Immunology, Organelles, Lymphokines, Immunization, Mitochondria, Nanoparticle, United States, Immunotherapy, Nanotechnology, Cancer Vaccines, Dendritic Cells, Immunomodulation, Interferon gamma, Biological Factors, Cellular Structures.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Vaccine Week


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